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ProteomicsPlasmodium berghei LAPs form an extended protein complex that facilitates crystalloid targeting and biogenesis
Passage of malaria parasites through mosquitoes involves multiple developmental transitions, from gametocytes that are ingested with the blood meal, through to sporozoites that are transmitted by insect bite to the host. During the transformation from gametocyte to oocyst, the parasite forms a uniqu...
ORGANISM(S): Plasmodium berghei 
2021-09-09 | PXD019454 | Pride
Plasmodium Proteomics Malaria Crystalloid Laps 
ProteomicsSARS-CoV-2 infection causes periodontal fibrotic pathogenesis through deregulating mitochondrial beta-oxidation
The global high prevalence of COVID-19 is a major challenge for health professionals and patients. SARS-CoV-2 virus has four kinds of structural protein components: the spike protein, envelope protein, membrane protein, and nucleocapsid protein. SARS-CoV-2 virus mutate predominantly in the spike pro...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD041281 | Pride
Covid19 Periodontal Infection 
ProteomicsSARS-CoV-2 non-spike structural proteins hijack mucosa epithelial cell fate
COVID-19 patients readily present with severe epithelial damages such as ulceration, erosions, loss of tissue repair etc. in multiple organs. Mucosa aligning such as lung alveoli, gastrointestinal tract, oral cavity are primary targets of SARS-CoV-2 infection. The infected epithelium triggers dysreg...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD060880 | Pride
Covid-19 Spike protein Sars-cov-2 Proteomics 
ProteomicsIntegrated proteomic, DNA methylation, and targeted Next Generation Sequencing reveals relevant heterogeneity in lower-grade meningioma and a new target in NF2 mutated meningiomas
Meningiomas, the most common primary brain tumours, are classified by the World Health Organization (WHO) into grades 1, 2, and 3. Some grade 1 tumours exhibit increased clinical aggressiveness with the biallelic mutation of Neurofibromatosis 2 (NF2) being the most frequent mutation reported. In our...
ORGANISM(S): Homo sapiens (Human) 
2025-07-02 | PXD058653 | Pride
Genomics Nf2 Proteomics Meningioma 
ProteomicsIntegrated proteomic, DNA methylation, and targeted Next Generation Sequencing reveals relevant heterogeneity in lower-grade meningioma and a new target in NF2 mutated meningiomas
Meningiomas, the most common primary brain tumours, are classified by the World Health Organization (WHO) into grades 1, 2, and 3. Some grade 1 tumours exhibit increased clinical aggressiveness with the biallelic mutation of Neurofibromatosis 2 (NF2) being the most frequent mutation reported. In our...
ORGANISM(S): Homo sapiens (Human) 
2025-07-02 | PXD058651 | Pride
Brain tumour Ngs Proteomics Meningioma 
ProteomicsProtein ubiquitylation is essential for the schizont to merozoite transition in Plasmodium falciparum blood-stage development
Ubiquitylation is a common post translational modification of eukaryotic proteins. Protein ubiquitylation increases in the transition from intracellular schizont to extracellular merozoite in the asexual blood stage cycle of the human malaria parasite, Plasmodium falciparum (Pf). Here, we identify s...
ORGANISM(S): Plasmodium falciparum 
2020-05-20 | PXD014998 | Pride
Proteomics Ubiquitylation Malaria Plasmodium 
ProteomicsVESICULATION OF RED BLOOD CELLS IN THE BLOOD BANK: A MULTI-OMICS APPROACH TOWARDS IDENTIFICATION OF CAUSES AND CONSEQUENCES
Microvesicle generation is an integral part of the aging process of red blood cells in vivo and in vitro. Extensive vesiculation impairs function and survival of red blood cells after transfusion, and microvesicles contribute to transfusion reactions. The triggers and mechanism of microvesicle gener...
ORGANISM(S): Homo sapiens (Human) 
2020-04-03 | PXD017056 | Pride
Metabolomics Blood Lipidomics Proteomics Rbc 
UnknownIdentification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2.
Not available
S-EPMC7441759 | biostudies-literature
UnknownStructure-Based Virtual Screening and Biochemical Validation to Discover a Potential Inhibitor of the SARS-CoV-2 Main Protease.
Not available
S-EPMC7754785 | biostudies-literature
UnknownRelationship of adipocyte size with adiposity and metabolic risk factors in Asian Indians.
Not available
S-EPMC4177391 | biostudies-literature
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