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ProteomicsAn increase in oxidative stress downstream of mTORC1 but not AKT causes a proliferative defect in cancer cells with acquired resistance to PI3K/mTOR inhibitors
Proteomics and phosphoproteomics analysis of MCF7 cells sensitive and resistant to the PI3K inhibitor GDC-0941. The analysis was done for parental and 3 resistant cell lines maintained in the presence or the absence of the drug. One of the resistant cell lines (G2) was also treated with vehicle or t...
ORGANISM(S): Homo sapiens (Human) 
2018-04-09 | PXD003594 | Pride
Human Phosphoproteomics Metabolism Ltq-orbitrap Tio2 Pi3k resistance Q-exactive plus 
UnknownA Crowdsourcing Approach to Develop Machine Learning Models to Quantify Radiographic Joint Damage in Rheumatoid Arthritis.
Not available
S-EPMC9425151 | biostudies-literature
UnknownStructural Diversity in Multicomponent Nanocrystal Superlattices Comprising Lead Halide Perovskite Nanocubes.
Not available
S-EPMC9134504 | biostudies-literature
MetabolomicsAnalysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesis
Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito vector. Not only are gametocytes able to survive in radically different host environments, but they are also precursors for male and female g...
2022-04-05 | MTBLS4137 | MetaboLights
MetabolomicsDNA-PKcs drives CKD progression by activating TAF7/RAPTOR/mTORC1 signaling-mediated metabolic reprogramming

Kidney injury initiates epithelial dedifferentiation and myofibroblast activation during the progression of chronic kidney disease (CKD). Herein, we found that the expression of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) was significantly increased in the kidney tissues of both CKD...

2023-01-25 | MTBLS5971 | MetaboLights
UnknownA revamped rat reference genome improves the discovery of genetic diversity in laboratory rats.
Not available
S-EPMC10197727 | biostudies-literature
UnknownA revamped rat reference genome improves the discovery of genetic diversity in laboratory rats.
Not available
S-EPMC11019364 | biostudies-literature
UnknownExpression quantitative trait locus fine mapping of the 17q12-21 asthma locus in African American children: a genetic association and gene expression study.
Not available
S-EPMC7335429 | biostudies-literature
UnknownExome-wide association study of plasma lipids in >300,000 individuals.
Not available
S-EPMC5709146 | biostudies-literature
UnknownTraumatic brain injury: progress and challenges in prevention, clinical care, and research.
Not available
S-EPMC10427240 | biostudies-literature
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