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ProteomicsIdentification of novel SHARPIN binders
Sharpin, a multifunctional adaptor protein with oncogenic properties, regulates several signalling pathways. For example, Sharpin enhances signal-induced NF-κB signalling as part of the linear ubiquitin assembly complex (LUBAC) and inhibits integrins, the T cell receptor, caspase1 and PTEN. However,...
ORGANISM(S): Homo sapiens (Human) 
2017-08-11 | PXD004734 | Pride
Sharpin Gfp pull-down Human 
GenomicsTranscriptomic profiling of human SHARPIN deficiency
Transcriptomic profiling of human SHARPIN deficiency
PRJNA1084850 | ENA
TranscriptomicsSharpin promotes hepatocellular carcinoma progression via transactivation of versican expression
Sharpin (Shank-associated RH domain-interacting protein, also known as SIPL1) is a multifunctional molecule that participates in various biological settings, including nuclear factor-κB signaling activation and tumor suppressor gene inhibition. Sharpin is upregulated in various types of cancers, inc...
ORGANISM(S): Homo sapiens 
2017-01-23 | GSE87149 | GEO
TranscriptomicsTranscriptomic profiling of human SHARPIN deficiency
The linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN, and is essential for proper immune responses. Patients with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation and glycogen storage. In mice, the loss of Sharpin leads to severe derma...
ORGANISM(S): Homo sapiens 
2024-03-07 | GSE261031 | GEO
GenomicsNext generation sequencing facilities quantitative analysis of SHARPIN knockout or non-target LoVo cells
Next generation sequencing facilities quantitative analysis of SHARPIN knockout or non-target LoVo cells
PRJNA1074367 | ENA
UnknownThe Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.
Not available
S-EPMC5612173 | biostudies-literature
TranscriptomicsGenome-wide expression change by SHARPIN knockdown in MCF-7 cells
We aim to investigate the role of SHARPIN in breast cancer progression. MCF-7 cells were used as the model and SHARPIN was silenced by siRNA.SHARPIN (SHANK-Associated RH Domain Interactor) is also named as SIPL1 and HSIPL1. The gene is located in Chr 8. SHARPIN protein is shown to regulate cell adhe...
ORGANISM(S): Homo sapiens 
2017-01-01 | GSE77261 | GEO
GenomicsExpression data from isolated SHARPIN-deficient thymic Treg cells
Expression data from isolated SHARPIN-deficient thymic Treg cells
PRJNA428601 | ENA
UnknownSHARPIN regulates uropod detachment in migrating lymphocytes.
Not available
S-EPMC3852511 | biostudies-literature
TranscriptomicsSharpin controls differentiation and cytokine production of mesenchymal bone marrow cells
The cytosolic protein Sharpin is as a component of the linear ubiquitin chain assembly complex (LUBAC), which regulates NF-κB signaling in response to specific ligands. Its inactivating mutation in Cpdm (chronic proliferative dermatitis mutation) mice causes multi-organ inflammation, yet this phenot...
ORGANISM(S): Mus musculus 
2015-09-07 | E-GEOD-61299 | biostudies-arrayexpress
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