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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
UnknownType II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography.
Not available
S-EPMC4919452 | biostudies-literature
UnknownProton-coupled electron transfer at a mis-metalated zinc site detected with protein charge ladders.
Not available
S-EPMC11350471 | biostudies-literature
Unknownm6Am methyltransferase PCIF1 is essential for aggressiveness of gastric cancer cells by inhibiting TM9SF1 mRNA translation.
Not available
S-EPMC9124189 | biostudies-literature
ProteomicsExtracellular matrix analysis of human keloid scars
Fibrosis is vaguely described as connective tissue deposition that can be excessive in pathological conditions. This suggests a quantitative spectrum of fibrosis wherein there can be more or less extracellular matrix (ECM), which in the context of a repairing skin wound could reflect the range from ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-03 | PXD015057 | Pride
Human skin scar dermis lc-ms/ms 
ProteomicsInsight into the Human Pathodegradome of the V8 protease from Staphylococcus aureus
The major human pathogen Staphylococcus aureus possesses ten extracellular proteases that are central to the virulence process. While some host targets of these and other bacterial proteases are known, a major bottleneck to the study of their function is the low-throughout nature of substrate identi...
ORGANISM(S): Homo sapiens (Human) Staphylococcus aureus 
2021-03-29 | PXD014797 | Pride
Host-pathogen interactions Immunology Microbiology N-terminomics Staphylococcus aureus Degradomics 
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
UnknownMechanistic and structural analyses of the roles of Arg409 and Asp402 in the reaction of the flavoprotein nitroalkane oxidase.
Not available
S-EPMC2526231 | biostudies-literature
UnknownExpanding the phenotype of SPONASTRIME dysplasia to include short dental roots, hypogammaglobulinemia, and cataracts.
Not available
S-EPMC6814188 | biostudies-literature
MetabolomicsEvidence of altered fatty acid metabolism in dogs with naturally occurring valvular heart disease and congestive heart failure

INTRODUCTION: Myxomatous mitral valve disease (MMVD) is the most common cardiac condition in adult dogs. The disease progresses over several years and affected dogs may develop congestive heart failure (HF). Research has shown that myocardial metabolism is altered in cardiac dise...

2022-03-31 | MTBLS716 | MetaboLights
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