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TranscriptomicsOncogenic MYC induces a dependency on the spliceosome in human cancer
c-MYC (MYC) overexpression or hyperactivation is one of the most common drivers of human cancer. Despite intensive study, the MYC oncogene remains recalcitrant to therapeutic inhibition. Like other classic oncogenes, hyperactivation of MYC leads to collateral stresses onto cancer cells, suggesting t...
ORGANISM(S): Homo sapiens 
2015-09-03 | E-GEOD-66182 | biostudies-arrayexpress
TranscriptomicsCapicua-dependent transcriptional changes in adult mouse cerebellum
Analysis of cerebella from Capicua (Cic) mutant mice and wild-type controls at 28 days of age (P28). Spinocerebellar ataxia type 1 (SCA1) is a fatal neurodegenerative disease caused by expansion of a translated CAG repeat in Ataxin-1 (ATXN1). The transcriptional repressor Cic binds directly to Atxn1...
ORGANISM(S): Mus musculus 
2011-11-07 | E-GEOD-32051 | biostudies-arrayexpress
TranscriptomicsAtxn1L is a novel regulator of Hematopoietic Stem Cell Quiescence
We compared gene expression differences in Atxn1L knockout vs wildtype HSCs KO allele described in Pub Med ID: 22014525 HSCs were purified as Lineage-negative, Sca-1+ c-Kit+ (LSK), CD150+ and Side population from both Atxn1L-null and WT mice on C57Bl/6 background
ORGANISM(S): Mus musculus 
2013-02-28 | E-GEOD-44285 | biostudies-arrayexpress
TranscriptomicsCerebellar gene expression data from Mecp2-null and MECP2-transgenic mice
We compared gene expression changes in the cerebellum of mice lacking MeCP2 (Mecp2-null) and mice overexpressing MeCP2 (MECP2-transgenic). A group of postnatal neurodevelopmental disorders collectively referred to as MeCP2 disorders are caused by aberrations in the gene encoding methyl-CpG-binding ...
ORGANISM(S): Mus musculus 
2010-04-10 | E-GEOD-15574 | biostudies-arrayexpress
UnknownSafety and immunogenicity of heterologous versus homologous prime-boost schedules with an adenoviral vectored and mRNA COVID-19 vaccine (Com-COV): a single-blind, randomised, non-inferiority trial.
Not available
S-EPMC8346248 | biostudies-literature
TranscriptomicsRacial Difference in Human Platelet PAR4 Reactivity Reflects Expression of PCTP and miR-376c
Racial differences in the pathophysiology of atherothrombosis are poorly understood. We explored the function and transcriptome of platelets in healthy black (n=70) and white (n=84) subjects. Numerous differentially expressed (DE) RNAs were associated with both race and PAR4 reactivity, including p...
ORGANISM(S): Homo sapiens 
2013-11-15 | E-GEOD-49921 | biostudies-arrayexpress
TranscriptomicsHypothalamic gene expression data from Mecp2-null and MECP2-transgenic mice
We compared gene expression changes in the hypothalamus of mice lacking MeCP2 (Mecp2-null) and mice overexpressing MeCP2 (MECP2-transgenic). Mutations in the gene encoding the transcriptional repressor methyl-CpG binding protein 2 (MeCP2) cause the neurodevelopmental disorder Rett syndrome. Loss of ...
ORGANISM(S): Mus musculus 
2008-05-30 | E-GEOD-11150 | biostudies-arrayexpress
TranscriptomicsPatient-derived Human Breast Cancer Xenografts
Breast cancer research is hampered by difficulties in obtaining and studying primary human breast tissue, and by the lack of in vivo preclinical models that reflect patient tumor biology accurately. To overcome these limitations, we propagated a cohort of human breast tumors grown in the epithelium-...
ORGANISM(S): Homo sapiens 
2013-05-30 | E-GEOD-46106 | biostudies-arrayexpress
TranscriptomicsAn essential role for the Gai2 protein in Smoothened-stimulated mammary epithelial cell proliferation
Hedgehog (Hh) signaling is critical for organogenesis, tissue homeostasis, and stem cell maintenance. Smoothened (SMO), the primary effector of Hh signaling, is expressed ectopically in human breast cancer, as well as in other cancers. Constitutive activation of SMO in mouse mammary glands leads t...
ORGANISM(S): Mus musculus 
2015-09-08 | E-GEOD-70210 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse mammary gland side population cells (MG-SPs) to identify differentially expressed genes.
Similar to the bone marrow, the mammary gland contains a distinct population of Hoechst-effluxing side population cells, MG-SPs. To better characterize MG-SPs, their microarray gene profiles were compared to the remaining cells, which retain Hoechst dye (MG-NSPs). For analysis, gene ontology (GO) t...
ORGANISM(S): Mus musculus 
2007-11-27 | E-GEOD-5309 | biostudies-arrayexpress
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