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ProteomicsExtracellular matrix analysis of human keloid scars
Fibrosis is vaguely described as connective tissue deposition that can be excessive in pathological conditions. This suggests a quantitative spectrum of fibrosis wherein there can be more or less extracellular matrix (ECM), which in the context of a repairing skin wound could reflect the range from ...
ORGANISM(S): Homo sapiens (Human) 
2019-12-03 | PXD015057 | Pride
Human skin scar dermis lc-ms/ms 
UnknownExtracellular proteases are key mediators of Staphylococcus aureus virulence via the global modulation of virulence-determinant stability.
Not available
S-EPMC3584211 | biostudies-literature
UnknownBexicaserin for the treatment of seizures in developmental and epileptic encephalopathies: A phase 1b/2a trial (PACIFIC).
Not available
S-EPMC12927688 | biostudies-literature
UnknownCamlipixant in Refractory Chronic Cough: A Phase 2b, Randomized, Placebo-controlled Trial (SOOTHE).
Not available
S-EPMC12180140 | biostudies-literature
ProteomicsGlobal Protein Abundance and Phosphorylation Analyses of Influenza A Virus (IAV)-Infected Human Cells
Influenza A Virus (IAV) is a recurring respiratory virus with antiviral therapies of limited use. Understanding host proteins essential for IAV infection can identify targets for alternative host-directed therapies (HDTs). Using affinity purification-mass spectrometry and global phosphoproteomic and...
ORGANISM(S): Homo sapiens (Human) 
2023-07-25 | PXD035900 | Pride
Human H5n1 H1n1 Protein abundance Phosphorylation Nhbe H3n2 Thp-1 Infection Influenza a virus 
TranscriptomicsLoss of nuclear TDP-43 in ALS causes altered expression of splicing machinery and widespread dysregulation of RNA splicing in motor neurons [NSC34]
Aims: Loss of nuclear TDP-43 characterises sporadic and most familial forms of amyotrophic lateral sclerosis (ALS). TDP-43 (encoded by TARDBP) has multiple roles in RNA processing. We aimed to determine whether 1) RNA splicing dysregulation is present in lower motor neurons in ALS and in a motor neu...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-56503 | biostudies-arrayexpress
UnknownEffectiveness of nirmatrelvir-ritonavir in preventing hospital admissions and deaths in people with COVID-19: a cohort study in a large US health-care system.
Not available
S-EPMC10081864 | biostudies-literature
MetabolomicsAntiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine is detectable in serum and identifies acute viral infections including COVID-19

BACKGROUND: There is a critical need for rapid viral infection diagnostics to enable prompt case identification in pandemic settings and support targeted antimicrobial prescribing.

METHODS: Using untargeted high-resolution liquid chromatography coupled with...

2022-02-10 | MTBLS718 | MetaboLights
UnknownA call for a community of practice to assess the impact of emerging technologies on undergraduate biology education.
Not available
S-EPMC3577284 | biostudies-literature
UnknownBreaking the Iron Homeostasis: A "Trojan Horse" Self-Assembled Nanodrug Sensitizes Homologous Recombination Proficient Ovarian Cancer Cells to PARP Inhibition.
Not available
S-EPMC9413404 | biostudies-literature
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