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TranscriptomicsIdentification of BORIS-bound transcripts in neural progenitor cells and young neurons
This study compares the transcripts bound to BORIS in neural progenitor cells and cells differentiated for 6 days into young neurons We present expression profiles for neural progenitor cells (arrays hybridised in triplicate) and in young neurons (arrays hybridised in duplicate). Immunoprecipitated ...
ORGANISM(S): Homo sapiens 
2013-11-29 | E-GEOD-42294 | biostudies-arrayexpress
ProteomicsMolecular analysis of brain tumour models
Pilocytic astrocytomas and other paediatric low-grade gliomas (pLGGs) are often considered single-pathway diseases due to the predominance of MAPK/ERK pathway alterations observed in these patients. However, emerging evidence suggests that the MAPK/ERK interacts within a complex signalling network t...
ORGANISM(S): Homo sapiens (Human) 
2025-05-14 | PXD060246 | Pride
Kiaa1549 Label-free proteomics Mapk Braf Plgg Phosphoproteomics Fgfr Lc-ms/ms 
TranscriptomicsMicroRNA expression profiles for paediatric brain tumours
In this study, we screened a cohort of 57 paediatric brain tumours, with a wide range of pathologies to identify microRNA profiles We analysed the microRNA profiles in paediatric brain tumours as compared to normal adult brain. Our cohort included 14 pilocytic astrocytomas, 3 diffuse astrocytomas, 2...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-42657 | biostudies-arrayexpress
TranscriptomicsGene expression profiles for paediatric brain tumours
In this study, we screened a cohort of 57 paediatric brain tumours, with a wide range of pathologies to identify gene expression profiles We analysed gene expression in paediatric brain tumours as compared to normal adult brain in order to understand the molecular profiles. Our cohort included 15 pi...
ORGANISM(S): Homo sapiens 
2013-07-29 | E-GEOD-42656 | biostudies-arrayexpress
TranscriptomicsExpression profiles for paediatric brain tumours
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-07-29 | E-GEOD-42658 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for low-grade astrocytoma samples
Copy number analysis of 21 paediatric low-grade astrocytomas identified a discrete copy number gain of 1.9Mb in chromosome band 7q34. The gain was present in 12/14 cerebellar pilocytic astrocytomas. Subsequent analysis of tumour cDNA indentified a novel gene fusion between KIAA1549 and BRAF in these...
ORGANISM(S): Homo sapiens 
2010-04-09 | E-GEOD-14960 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood monocytes from a patient with a heterozygous deletion of the CARMA1 gene cultured with anti-CD3, anti-CD3 and anti-CD28 or lipopolysaccharide
PBMCs were isolated from whole blood taken from one patient and one healthy control. Cells were cultured in media (RPMI) alone, with 1µg/ml anti-CD3, with 1µg/ml anti-CD3 & 1µg/ml anti-CD28 or with 0.5ng/ml LPS. Cells were harvested after 24 or 48 hours, RNA isolated using Trizol, purified using R...
ORGANISM(S): Homo sapiens 
2022-04-01 | E-MTAB-101 | biostudies-arrayexpress
TranscriptomicsTiling path analysis to map chromatin anchors within the human Major Histocompatability Complex region from B-lymphoblastoid cells and IFNg+/IFNg- treated fibroblasts
Mapping of chromatin anchors within the human Major Histocompatability Complex (MHC) region from B-lymphoblastoid cells and IFNg+/IFNg- treated fibroblasts.
ORGANISM(S): Homo sapiens 
2008-10-01 | E-MEXP-1793 | biostudies-arrayexpress
TranscriptomicsGenomic anchors across the MHC of MRC5 cells upon treatment with IFN-gamma: Loop associated DNA vs Matrix associated DNA
Identification of genomic anchors across the MHC in untreated MRC5 fibroblasts, and fibroblasts treated with IFN-gamma, using high resolution microarrays. Identification of genomic anchors using MRC5 fibroblasts, and fibroblasts treated with IFN-gamma: Loop associated DNA vs Matrix associated DNA, 2...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-35845 | biostudies-arrayexpress
TranscriptomicsGenome-wide methylation analysis and gene expression profiling identifies genes silenced in non-seminoma cell lines [gene expression]
Germ cell tumours (GCTs) are a complex group of malignancies. They are unique in developing from a pluripotent progenitor cell. The initial lesion is believed to be the relatively benign precursor lesion (ICGNU), from which either highly chemosensitive seminomas or the more aggressive non-seminomas ...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-65026 | biostudies-arrayexpress
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