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TranscriptomicsPredicting the efficacy of anthracyclines in breast cancer (BC) patients: The results of the TOP trial
PURPOSE: Validated biomarkers predictive of response/resistance to anthracyclines in breast cancer are currently lacking. The neoadjuvant TOP trial, in which patients with estrogen receptor (ER)-negative tumors were treated with anthracycline (epirubicin) monotherapy, was specifically designed to ev...
ORGANISM(S): Homo sapiens 
2010-01-26 | E-GEOD-16446 | biostudies-arrayexpress
TranscriptomicsmicroRNA expression profiling of early primary breast cancer to identify prognostic markers and associated pathways
Retrospective series of primary breast cancer patients who received surgery between 1989 and 1992. Patients received adjuvant chemotherapy and/or adjuvant hormone therapy, or no adjuvant treatment. Tamoxifen was used as endocrine therapy for 5 years in ER+ BC patients. Patients who were <50 years of...
ORGANISM(S): Homo sapiens 
2011-07-08 | E-GEOD-22216 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of early primary breast cancer to identify prognostic markers and associated pathways
Retrospective series of primary breast cancer patients who received surgery between 1989 and 1992. Patients received adjuvant chemotherapy and/or adjuvant hormone therapy, or no adjuvant treatment. Tamoxifen was used as endocrine therapy for 5 years in ER+ BC patients. Patients who were <50 years of...
ORGANISM(S): Homo sapiens 
2011-07-08 | E-GEOD-22219 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human breast cancer cell line MCF7 under conditions of hypoxia
Hypoxia results in the changes in expression of many genes, the majority of which are mediated via the transcriptional activity of the hypoxia inducible factor (HIF) complex. However, other mechanisms of gene regulation by hypoxia are likely and include control of mRNA stability, regulation of mRN...
ORGANISM(S): Homo sapiens 
2008-03-01 | E-MEXP-1111 | biostudies-arrayexpress
TranscriptomicsSingle cell RNA-sequencing of normal breast tissue samples before and after 12-week anti-progestin (ulipristal acetate) treatment
Vacuum-assisted biopsy (VAB) from normal breast tissue were obtained from women participating in the Breast Cancer - Anti-Progestin Prevention Study 1 (BC-APPS1). A baseline VAB was performed in the luteal phase of the menstrual cycle and a second VAB was performed after a 12-week anti-progestin (ul...
ORGANISM(S): Homo sapiens 
2025-09-08 | E-MTAB-13819 | biostudies-arrayexpress
UnknownEmergence of a novel avian pox disease in British tit species.
Not available
S-EPMC3504035 | biostudies-literature
UnknownAntibody responses to avian influenza viruses in wild birds broaden with age.
Not available
S-EPMC5204166 | biostudies-literature
TranscriptomicsTumor expression data from neoadjuvant trial of cisplatin monotherapy in triple negative breast cancer patients
Evidence suggests that BRCA1 mutation associated tumors have increased sensitivity to DNA damaging agents like cisplatin. Sporadic triple negative breast cancers (TNBC) have many phenotypic similarities to BRCA1 tumors and may have a similar sensitivity to cisplatin. We tested the efficacy of cisp...
ORGANISM(S): Homo sapiens 
2009-11-04 | E-GEOD-18864 | biostudies-arrayexpress
TranscriptomicsCombinatorial Inhibition of Menin and the Histone Methyltransferase DOT1L as a Novel Therapeutic Strategy for Ovarian Cancer Treatment
Descrizione ProvvisoriaPurpose OC is characterized by a low response rate and high frequency of resistance development to currently available treatments, indicating to an urgent need for the identification of novel and more effective therapies. Several studies demonstrated DOT1L therapeutic potentia...
ORGANISM(S): Homo sapiens 
2026-08-01 | E-MTAB-11800 | biostudies-arrayexpress
Transcriptomics4C-seq to detect the interaction of the EVI1 promoter (viewpoint of the experiment) with chromatin regulatory elements in a selection of ovarian cancer cell lines and other cancer cell lines
The EVI1 promoter was chosen as the viewpoint of the experiment. The purpose of this experiment was to detect potential cis-interactions of the EVI1 promoter with regulatory elements. 4C-seq was performed in the ovarian cancer cell lines COV-434, ES-2, Kuramochi, OAW28, OAW42, OVISE, SKOV-3, TOV-112...
ORGANISM(S): Homo sapiens 
2026-07-30 | E-MTAB-14772 | biostudies-arrayexpress
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