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GenomicsATRX tolerates activity-dependent histone H3 M-bM-^@M-^\methyl/phos switchingM-bM-^@M-^] to maintain repetitive element silencing in neurons
ATRX is a member of the SWI2/SNF2 family of chromatin remodeling proteins and primarily functions at heterochromatic loci via its recognition of M-bM-^@M-^XrepressiveM-bM-^@M-^Y histone modifications (e.g., H3K9me3). Despite significant roles for ATRX during normal neural development, as well as its...
ORGANISM(S): Mus musculus 
2015-01-02 | E-GEOD-64062 | biostudies-arrayexpress
UnknownHighly efficient recycling of polyester wastes to diols using Ru and Mo dual-atom catalyst.
Not available
S-EPMC11224329 | biostudies-literature
MetabolomicsPlasma metabolite changes in dairy cows during parturition identified using untargeted metabolomics
The metabolic responses of cows undergo substantial changes during the transition from late pregnancy to early lactation. However, the molecular mechanisms associated with these changes in physiological metabolism have not been clearly elucidated. The objective of this study was to investigate metab...
2019-08-20 | MTBLS809 | MetaboLights
TranscriptomicsGene expression data from MDA-MB231 cells stably transduced with lentiviral vectors encoding a control shRNA (shscramble) or two shRNAs targeting Coco (shco2 and shco4)
Metastatic relapse of breast cancer and other tumor types usually occurs several years after surgical resection of the primary tumor. Early dissemination of tumor cells followed by an extended period of dormancy is thought to explain this prevalent clinical behavior. By using a gain-of-function retr...
ORGANISM(S): Homo sapiens 
2012-08-16 | E-GEOD-28049 | biostudies-arrayexpress
UnknownSystemic coccidioidomycosis in a llama cria native to Missouri.
Not available
S-EPMC8120084 | biostudies-literature
TranscriptomicsHormonal Regulation of MicroRNA Expression in Rat Adrenal Gland
To determine miRNA profiles in rat adrenals from animals treated with vehicle, ACTH, 17M-NM-1-ethinyl estradiol (17M-NM-1-E2) or dexamethasone (DEX). miRNA expression profiling was performed using AffymetrixM-BM-. GeneChipM-BM-. miRNA 2.0 Arrays. Together with qRT-PCR, several adrenal miRNAs have b...
ORGANISM(S): Rattus norvegicus 
2014-05-16 | E-GEOD-47131 | biostudies-arrayexpress
TranscriptomicsGenome-wide profiling of gene expression of normal and Tbx20 knockout adult mouse whole heart
Tbx20 is a transcription factor important for heart development. To assess the role of Tbx20 in the adult heart, we generated a conditional knockout for this gene, specifically in cardiomyocytes. We profiled gene expression levels using RNA-seq in both normal and knockout adult mouse hearts to ident...
ORGANISM(S): Mus musculus 
2012-02-10 | E-GEOD-30943 | biostudies-arrayexpress
GenomicsChIP-Seq data from Arabidopsis thaliana under dark and far-red light
FAR-RED ELONGATED HYPOCOTYL 3 (FHY3) and its homolog FAR-RED IMPAIRED RESPONSE 1 (FAR1) are two transposase-derived transcription factors initially identified as the key components in phytochrome A signaling and recently shown to function in the circadian clock. However, whether FHY3 and FAR1 are in...
ORGANISM(S): Arabidopsis thaliana 
2011-08-02 | E-GEOD-30711 | biostudies-arrayexpress
UnknownSuppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion.
Not available
S-EPMC6123498 | biostudies-literature
TranscriptomicsProfiling downregulation of the mevalonate pathway in Staphylococcus aureus
Isoprenoids are a class of ubiquitous organic molecules synthesized from the five-carbon starter unit isopentenyl pyrophosphate (IPP). Comprising more than 30,000 known natural products, isoprenoids serve various important biological functions in many organisms. In bacteria, undecaprenyl pyrophospha...
ORGANISM(S): Staphylococcus aureus RN4220 
2010-05-05 | E-GEOD-13424 | biostudies-arrayexpress
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