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UnknownCausal association of metabolic syndrome with chronic kidney disease progression: A Mendelian randomization study.
Not available
S-EPMC12118223 | biostudies-literature
UnknownThe BDNF Val66Met polymorphism is associated with the functional connectivity dynamics of pain modulatory systems in primary dysmenorrhea.
Not available
S-EPMC4806293 | biostudies-literature
ProteomicsSIRT6 phosphorylation - MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer
Sirtuin 6 (SIRT6) is associated with longevity and was recently established as a tumor suppressor. Hence, identifying the molecular regulators of SIRT6 might enable its activation therapeutically in cancer patients. We found that SIRT6 was phosphorylated by the kinase AKT1 at Ser338, which induces i...
ORGANISM(S): Homo sapiens (Human) 
2016-07-06 | PXD001154 | Pride
Phosphorylation Sirt6 
UnknownMDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer.
Not available
S-EPMC4161976 | biostudies-literature
TranscriptomicsGenome-wide analysis of gene expression patterns in mir-122 knockout mice livers
To invesigate the physiology roles of mir-122 in liver, we performed expression profiling of mir-122 knockout mice and the control B6/129 mice. Total RNA was extracted from four mir-122 knockout mice and three control mice of 2 months of age. Gene expression was quantified by robust multi-array anal...
ORGANISM(S): Mus musculus 
2012-08-06 | E-GEOD-27713 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression patterns in the liver tumors of mir-122 knockout mice
To invesigate the physiological roles of mir-122 in hepatocarcinogenesis, we performed expression profiling of the liver tumors of mir-122 knockout mice and the liver tissues of the control B6/129 mice. Total RNA was extracted from three tumors of mir-122 knockout mice and liver tissues of two cont...
ORGANISM(S): Mus musculus 
2012-08-06 | E-GEOD-31453 | biostudies-arrayexpress
UnknownERα determines the chemo-resistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions.
Not available
S-EPMC8463322 | biostudies-literature
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
UnknownAnti-inflammatory effect of euphane- and tirucallane-type triterpenes isolated from the traditional herb Euphorbia neriifolia L.
Not available
S-EPMC10326319 | biostudies-literature
UnknownCancer incidence in relation to body fatness among 0.5 million men and women: Findings from the China Kadoorie Biobank.
Not available
S-EPMC7614994 | biostudies-literature
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