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UnknownParathyroid hormone-like hormone (PTHLH) represses decidualization of human uterine fibroblast cells by an autocrine/paracrine mechanism.

Context

Parathyroid hormone-like hormone (PTHLH) is abundantly expressed by human endometrial stromal cells during decidualization. However, the role for PTHLH in the decidualization process is unknown.

Objective

To examine the effects of PTHLH on the induction and maintenance of deci...
S-EPMC3048318 | biostudies-literature
UnknownBetween a Rock and a Hard Place: How poverty and lack of agency affect HIV risk behaviors among married women in 25 African countries: A cross-sectional study.

Background

Gender inequality and poverty exacerbate the burden of HIV/AIDS among women in Africa. AIDS awareness and educational campaigns have been inadequate in many countries and rates of HIV testing and adherence to condom use remains considerably low, especially among married women. We ...
S-EPMC8564885 | biostudies-literature
UnknownAn aligned framework of actively collected and passively monitored clinical outcome assessments (COAs) for measure selection.
Regulators increasingly require clinical outcome assessment (COA) data for approval. COAs can be collected via questionnaires or digital health technologies (DHTs), yet no single resource provides a side-by-side comparison of tools that collect complementary or related COA measures. We propose how t...
S-EPMC10944461 | biostudies-literature
UnknownAssociations between adiposity and indicators of thyroid status in children and adolescents.

Background

In adults, obesity is associated with abnormalities of thyroid function; there are fewer studies in paediatric cohorts.

Objectives

To examine associations of weight and adiposity with indices of thyroid function and thyroid-related metabolic factors in children.

Design/m...

S-EPMC5722653 | biostudies-literature
UnknownA longitudinal study of serum insulin and insulin resistance as predictors of weight and body fat gain in African American and Caucasian children.

Background

The influence of insulin and insulin resistance (IR) on children's weight and fat gain is unclear.

Objective

To evaluate insulin and IR as predictors of weight and body fat gain in children at high risk for adult obesity. We hypothesized that baseline IR would be positively...
S-EPMC5209266 | biostudies-literature
UnknownA mouse model for a partially inactive obesity-associated human MC3R variant.
We previously reported children homozygous for two MC3R sequence variants (C17A+G241A) have greater fat mass than controls. Here we show, using homozygous knock-in mouse models in which we replace murine Mc3r with wild-type human (MC3R(hWT/hWT)) and double-mutant (C17A+G241A) human (MC3R(hDM/hDM)) M...
S-EPMC4738366 | biostudies-literature
UnknownIran Quality of Care in Medicine Program (IQCAMP): Design and Outcomes.

Background

Assessment of quality and cost of medical care has become a core health policy concern. We conducted a nationwide survey to assess these measures in Iran as a developing country. To present the protocol for the Iran Quality of Care in Medicine Program (IQCAMP) study, which estimat...
S-EPMC10685727 | biostudies-literature
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