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TranscriptomicsTranscriptomic analysis of vulvovaginal candidiasis identifies a role for the NLRP3 inflammasome
RNA-seq analysis of an in vivo murine model of vulvovaginal candidiasis Murine vaginas were infected with Candida albicans and harvested for RNA-seq analysis 3 days post-infection
ORGANISM(S): Mus musculus 
2015-04-11 | E-GEOD-67688 | biostudies-arrayexpress
TranscriptomicsUnique gene program of rat mesenteric arteries as revealed by Deep RNA Sequencing
This study used Deep RNA sequencing to define gene expression in the small resistance arteries and compare to a reference conduit artery, the aorta Methods: Deep RNA Sequencing (~90 million reads) was performed on 2 samples of adult SD rat mesenteric arteries and compared to that of 2 samples of aor...
ORGANISM(S): Rattus norvegicus 
2015-07-13 | E-GEOD-64450 | biostudies-arrayexpress
TranscriptomicsCharacterization of transcriptome dynamics in response to contact with host cells
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-03-30 | E-GEOD-56093 | biostudies-arrayexpress
TranscriptomicsmiRNA expression data from normal and Malignant hematopoietic cells
This data was used to identify miRNA signatures that can be used to calssify specific leukemia types including AML, precursor B ALL, precursor T ALL, and normal hematopoietic progenitor and mature populations This data was used to identify miRNA signatures that can be used to calssify specific leuke...
ORGANISM(S): Homo sapiens 
2013-10-31 | E-GEOD-51908 | biostudies-arrayexpress
TranscriptomicsMacrophage Gene Expression Upon Infection with Anaplasma phagocytophilum in the Presence and Absence of the Tick Salivary Protein SL2
Previously, we observed that a tick salivary protein named sialostatin L2 (SL2) mitigates caspase 1-mediated inflammation upon Anaplasma phagocytophilum infection. Here we are performing next-generation sequencing to determine the global effect of SL2 upon A. phagocytophilum infection of macrophages...
ORGANISM(S): Mus musculus 
2016-07-18 | E-GEOD-63647 | biostudies-arrayexpress
TranscriptomicsCharacterization of transcriptome dynamics in response to contact with host cells [Phase I In Vitro]
Candida albicans is the major invasive fungal pathogen of humans, causing diseases ranging from superficial mucosal infections to disseminated, systemic infections which are often life threatening. Hematogenously disseminated candidiasis (HDC) has a 47% mortality rate despite current antifungal ther...
ORGANISM(S): Candida albicans 
2014-03-30 | E-GEOD-56091 | biostudies-arrayexpress
TranscriptomicsDNMT inhibition in the Neonatal Preoptic Area
PN2 male and female rat pups were treated with vehicle or zebularine. POA RNA was extracted and sequenced to deterime the effects of DNMT inhibition in POA gene expression. Males and Females were treated with either vehicle (0.1% DNMSO in saline) or Zebularine
ORGANISM(S): Rattus norvegicus 
2015-03-30 | E-GEOD-66203 | biostudies-arrayexpress
TranscriptomicsCharacterization of transcriptome dynamics in response to contact with host cells [Phase II In Vivo]
Candida albicans is the major invasive fungal pathogen of humans, causing diseases ranging from superficial mucosal infections to disseminated, systemic infections which are often life threatening. Hematogenously disseminated candidiasis (HDC) has a 47% mortality rate despite current antifungal ther...
ORGANISM(S): Candida albicans 
2014-03-30 | E-GEOD-56092 | biostudies-arrayexpress
TranscriptomicsMNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL
The phosphorylation of eIF4E1 at serine 209 by MNK1 or MNK2 has been shown to initiate oncogenic mRNA translation, a process that favours cancer development and maintenance. Here, we interrogate the MNK-eIF4E axis in diffuse large B-cell lymphoma (DLBCL) and show a distinct distribution of MNK1 and ...
ORGANISM(S): Homo sapiens 
2014-11-18 | E-GEOD-61691 | biostudies-arrayexpress
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