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TranscriptomicsRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation [array]
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-52231 | biostudies-arrayexpress
GenomicsRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation [ChIP-Seq]
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-52277 | biostudies-arrayexpress
TranscriptomicsRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (4C-seq)
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-52595 | biostudies-arrayexpress
TranscriptomicsRole of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation (RNA-seq)
Cancer cells frequently depend on chromatin regulatory activities to maintain a malignant phenotype. Here, we show that leukemia cells require the mammalian SWI/SNF chromatin remodeling complex for their survival and aberrant self-renewal potential. While Brg1, an ATPase subunit of SWI/SNF, is known...
ORGANISM(S): Mus musculus 
2013-12-02 | E-GEOD-52623 | biostudies-arrayexpress
ProteomicsLC-MS of Asobara japonica venom protein
Venom protein LC-MS of the parasitoid wasp Asobara japonica
ORGANISM(S): Asobara japonica 
2026-01-26 | PXD059653 | Pride
Asobara japonica venom 
TranscriptomicsRNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukemia
Epigenetic pathways regulate gene expression by controlling and interpreting chromatin modifications. Cancer cells are characterized by altered epigenetic landscapes and commonly exploit the chromatin regulatory machinery to enforce oncogenic gene expression programs. While chromatin alterations are...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-GEOD-29799 | biostudies-arrayexpress
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