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MetabolomicsA Comprehensive and Ultrasensitive Isotope Calibration Method for Soil Amino Compounds Using Orbitrap Mass Spectrometry
Bound amino compounds (amino acid and amino sugar polymers) comprise a significant proportion (~40%) of soil organic nitrogen and therefore represent an essential source of nitrogen for plant and microbial nutrition. The analysis of their content and isotope enrichment still represents a significant...
2025-06-16 | MTBLS12550 | MetaboLights
ProteomicsAn Integrative multi-omics landscape of SARS-CoVs NSP3
Proteomic analysis of SARS-CoV NSP3 expressing cells
ORGANISM(S): Homo Sapiens 
2021-11-03 | PXD023927 |
ProteomicsStudying the role of RPL39L in mouse spermatogenesis
Proteostasis regulated by RPL39L maintains mouse spermatogenesis
ORGANISM(S): Mus Musculus 
2021-10-22 | PXD029274 |
ProteomicsUnveiling Biomarkers of Telitacicept’s Efficacy in SLE Treatment Through Proteomics
Our study is highly relevant to the fields of Medical Bioinformatics and Personalised Medicine, as it employs high-throughput omics technologies and bioinformatics analyses to uncover personalized biomarkers predictive of treatment response, thereby paving the way for tailored therapeutic strategi...
ORGANISM(S): Homo Sapiens 
2026-02-02 | PXD073923 |
ProteomicsAn antibody drug conjugate-like agent DTLL sensitizes gemcitabine-sensitive/resistant pancreatic cancer on basis of SMAD4 profiles
Chemoresistance to gemcitabine limits its clinical implementation for pancreatic ductal adenocarcinoma (PDAC). We previously generated an antibody drug conjugate (ADC) -like agent, EGFR/HER2 dual-targeting ligand-based lidamycin (DTLL), and studied the effect of DTLL combined with gemcitabine and th...
ORGANISM(S): Homo Sapiens 
2022-03-02 | PXD031977 |
ProteomicsSS18/BAFs regulate chromatin accessibility dynamics during pluripotent-somatic transition
The exit from pluripotency or pluripotent-somatic transition (PST) landmarks an event of mammalian development, and is also a representative cell-fate transition model, but remains largely unresolved. Recently, we reported construction of robust JUN-induced PST completed in one cell cycle and whose ...
ORGANISM(S): Mus Musculus 
2021-10-22 | PXD029277 |
ProteomicsSS18 regulates pluripotent-somatic transition through phase separation
The transition from pluripotent to somatic states marks a critical event in mammalian development, but remains largely unresolved. Here we report the identification of SS18 as a regulator for pluripotent to somatic transition or PST by CRISPR-based whole genome screens. Mechanistically, SS18 forms m...
ORGANISM(S): Mus Musculus 
2021-05-23 | PXD026208 |
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