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TranscriptomicsRNA polyadenylation landscape in human and mouse cells
Alternative polyadenylation (APA) of mRNAs has emerged as an important mechanism for post-transcriptional gene regulation in higher eukaryotes. Although microarrays have recently been used to characterize APA globally, they have a number of serious limitations that prevents comprehensive and highly ...
ORGANISM(S): Mus musculus 
2011-02-26 | E-GEOD-25450 | biostudies-arrayexpress
ProteomicsLENG8 mediates nuclear retention and degradation of misprocessed mRNAs and noncoding RNAs
Incompletely processed and misprocessed mRNAs as well as numerous noncoding RNAs are retained in the nucleus and often degraded, and defects in this quality control mechanism have been linked to various diseases, including cancer and neurodegeneration. However, the underlying mechanisms remain poorl...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD065356 | Pride
Misprocessed rnas Rna nuclear retention Rna degradation Leng8 
MetabolomicsThe trans-omics landscape of COVID-19
The outbreak of coronavirus disease 2019 (COVID-19) is a global health emergency. Various omics results have been reported for COVID-19, but the molecular hallmarks of COVID-19, especially in those patients without comorbidities, have not been fully investigated. Here we collect blood samples from 2...
2021-10-06 | MTBLS2542 | MetaboLights
TranscriptomicsCoupling between alternative polyadenylation and alternative splicing is limited to terminal introns
Alternative polyadenylation has been implicated as an important regulator of gene expression. In some cases, alternative polyadenylation is known to couple with alternative splicing to influence last intron removal. However, it is unknown whether alternative polyadenylation events influence alternat...
ORGANISM(S): Homo sapiens 
2016-03-14 | E-GEOD-79157 | biostudies-arrayexpress
ProteomicsTranscriptomic and Proteomic Signatures of Stemness and Differentiation in the Colon Crypt
The intestinal epithelium is replaced weekly by non-quiescent stem cells with kinetics that rely on a rapid loss of stemness and choice for secretory or absorptive lineage differentiation. To determine how the cellular transcriptome and proteome changes during these transitions, we developed a new c...
ORGANISM(S): Mus Musculus (mouse) 
2020-07-15 | PXD019351 | JPOST Repository
ProteomicsCSTB increases autophagic flux by sustaining the proteolytic activity of Cathepsin B and fuels glycolysis in pancreatic cancer
Cathepsins interact with CSTB were analysed by LC/MS
ORGANISM(S): Homo Sapiens 
2022-11-05 | PXD037970 |
ProteomicsCDK5RAP3, a UFL1 substrate adaptor, is critical for liver development
Protein modification by ubiquitin and ubiquitin-like proteins (UBLs) regulates numerous biological functions. The UFM1 system, a novel UBL conjugation system, is implicated in mouse development and hematopoiesis. However, its broad biological functions and working mechanisms remain largely elusive. ...
ORGANISM(S): Mus Musculus 
2019-01-14 | PXD012340 |
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