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TranscriptomicsThe addition of chromosome 8 leads to characteristic dysregulation of gene expression on all chromosome and transformed-associated phenotypes
To examain effects of trisomy 8 on gene expression in normal human cells, we have employed whole genome microarray expression profiling. To study the effects of aneuploidy in normal human cells, we generated cells which are artificially trisomic chromosome 8 (trisomy 8) using human primary fibroblas...
ORGANISM(S): Homo sapiens 
2011-10-07 | E-GEOD-28076 | biostudies-arrayexpress
TranscriptomicsMicroarray-based global mapping of integration sites of retrotransposon, intracisternal A-particle, in mouse genome
Mammalian genomes have evolutionary harbored numerous mobile elements, a part of which are still active and evoke genomic instability. Their movement and positional diversity occasionally result in phenotypic changes and variation by causing altered expression and disruption of neighboring genes in...
ORGANISM(S): Mus musculus 
2008-05-03 | E-GEOD-9572 | biostudies-arrayexpress
TranscriptomicsBiallelic and complicated inactivation of Pten in radiation-induced mouse thymic lymphomas
Inactivation of Pten occurs by multiple mechanisms including epigenetic silencing, point mutations, insertion, and deletion, which are tissue dependent. Although frequent loss of heterozygosity around Pten locus and plausible involvement of epigenetic silencing have been reported in radiation-induce...
ORGANISM(S): Mus musculus 
2010-05-06 | E-GEOD-17751 | biostudies-arrayexpress
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, expression
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19360 | biostudies-arrayexpress
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, aCGH 2
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19382 | biostudies-arrayexpress
TranscriptomicsIntegrated array-CGH and expression microarray analyses on medulloblastomas in heterozygous Ptch1 mice, aCGH 1
Genomic radiation signature illuminates low-dose effects with sharply reflected transcriptome in Ptch1-deficient medulloblastomas. Cancer risks of low-dose radiation are of great concern especially in relation to rapidly increasing medical exposures; however, their accurate assessments cope with man...
ORGANISM(S): Mus musculus 
2010-07-14 | E-GEOD-19381 | biostudies-arrayexpress
UnknownDeciphering state-dependent immune features from multi-layer omics data at single-cell resolution.
Not available
S-EPMC12339405 | biostudies-literature
UnknownSingle-cell analyses and host genetics highlight the role of innate immune cells in COVID-19 severity.
Not available
S-EPMC10181941 | biostudies-literature
UnknownThe whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force.
Not available
S-EPMC9395416 | biostudies-literature
UnknownBlood DNA virome associates with autoimmune diseases and COVID-19.
Not available
S-EPMC11735405 | biostudies-literature
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