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Transcriptomicsmer1D_SK1, mer2D_SK1, mer3D_SK1, spo22D_SK1, and spo70D_SK1 on expression/splicing microarrays
mer1D_SK1, mer2D_SK1, mer3D_SK1, spo22D_SK1, spo70D_SK1 late 9h meiotic time point. mer1D, mer2D, mer3D, spo22D diploid, and spo70D diploid was generated in the SK1 strain background (ATCC: MYA-2089) by PCR-mediated cassette-based gene replacement where the MER1, MER2, MER3, SPO22, or SPO70 ORF resp...
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-05 | E-GEOD-24678 | biostudies-arrayexpress
TranscriptomicsCompetition between pre-mRNAs for a limiting splicing machinery drives global changes in splicing
During meiosis in yeast, global splicing efficiency increases. The mechanism for this is relief of competition for the splicing machinery by repression of intron-containing ribosomal protein genes (RPGs). Repression of RPGs with rapamycin also increases splicing efficiency in vegetative cells. Reduc...
ORGANISM(S): Saccharomyces cerevisiae 
2013-10-22 | E-GEOD-44219 | biostudies-arrayexpress
Transcriptomicsume6D_BY4741 on expression/splicing microarrays
ume6D_BY4741 vegetative RNA compared to WT_BY4741 vegetative RNA. ume6D haploid was generated in the BY4741 strain background (ATCC: 201388) by PCR-mediated cassette-based gene replacement where the UME6 ORF was replaced with KANMX6, the deletion was verified by PCR. Vegetatively grown; Dye swap; Re...
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-05 | E-GEOD-24680 | biostudies-arrayexpress
TranscriptomicsAnalyzing the role of transcription elongation factors Spt4-5 in splicing
A set of 22 expts. aimed at identifying splicing events dependent upon on the Spt4-5 transcription elongation factors in yeast. Four spt mutants and an mRNA capping mutant were analyzed four times each, including biological and technical (dye-swap) replicates. Two wt vs wt expts. were also perform...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-09 | E-GEOD-1610 | biostudies-arrayexpress
TranscriptomicsRbfox1 downregulation and altered Calpain 3 splicing by FRG1 in a mouse model of facioscapulohumeral muscular dystrophy (FSHD).
FRG1 over-expression results in an FSHD-like phenotype in mice. Muscles (vastus lateralis and biceps brachii) from wild type and FRG1 over-expressing mice were compared at 4 and 13 weeks of age by splicing sensitive microarray. Comparisons at 4 different time points/muscles were performed between gr...
ORGANISM(S): Mus musculus 
2012-12-01 | E-GEOD-32073 | biostudies-arrayexpress
TranscriptomicsMuscleblind-Like 2 Mediated Alternative Splicing in the Developing Brain
We have characterized the MBNL2-dependent changes in expression and alternative splicing by comparing hippocampi from MBNL2 deltaE2/deltaE2 and WT mouse brains. 6 total samples were analyzed: brains from 3 WT and 3 MBNL2 deltaE2/deltaE2 female mice, all 2-3 months of age.
ORGANISM(S): Mus musculus 
2012-08-16 | E-GEOD-37908 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide regulation of pre-mRNA splicing and expression by the RNA-binding protein Quaking during monocyte to macrophage differentiation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-01-04 | E-GEOD-74979 | biostudies-arrayexpress
TranscriptomicsQuaking is a global regulator of muscle-specific alternative splicing in vertebrates [differentiation data]
This work provides the first evidence that Qk is a global regulator of splicing in vertebrates, defines a new splicing regulatory network in muscle, and suggests that overlapping splicing networks contribute to the complexity of changes in alternative splicing during differentiation. Alternative spl...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-40956 | biostudies-arrayexpress
TranscriptomicsQuaking is a global regulator of muscle-specific alternative splicing in vertebrates [siRNA data]
This work provides the first evidence that Qk is a global regulator of splicing in vertebrates, defines a new splicing regulatory network in muscle, and suggests that overlapping splicing networks contribute to the complexity of changes in alternative splicing during differentiation. Alternative spl...
ORGANISM(S): Mus musculus 
2013-06-05 | E-GEOD-40961 | biostudies-arrayexpress
TranscriptomicsGenome-wide Analysis Reveals SR Protein Cooperation and Competition in Regulated Splicing
SR proteins are well-characterized RNA binding proteins that promote exon inclusion by binding to exonic splicing enhancers (ESEs). However, it has been unclear whether regulatory rules deduced on model genes apply generally to activities of SR proteins in the cell. Here, we report global analyses o...
ORGANISM(S): Mus musculus 
2013-04-05 | E-GEOD-44591 | biostudies-arrayexpress
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