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ProteomicsO-GlcNAcylation enhances double strand break repair, promotes cancer cell proliferation and prevents therapy-induced senescence in irradiated tumors
The metabolic reprogramming associated with characteristic increases in glucose and glutamine metabolism common in advanced cancer is often ascribed to answering a higher demand for metabolic intermediates required for rapid tumor cell growth. Instead, recent discoveries have pointed to an alternati...
ORGANISM(S): Homo sapiens (Human) 
2019-04-30 | PXD010820 | Pride
Hbp pathway Mass spectrometry Dna repair Shoga Lfq quantification Shogt O-glcnacylation Chromatin modification Q-exactive 
GenomicsO-GlcNAcylation regulates c-Myc/PDK2 axis to rewire TCA cycle and promote colorectal tumor growth
O-GlcNAcylation regulates c-Myc/PDK2 axis to rewire TCA cycle and promote colorectal tumor growth
PRJNA971495 | ENA
ProteomicsQuantitative O-GlcNAc proteome reveals OGT-mediated post-translational regulatory network in canine osteosarcoma cells
This study performed label-free O-GlcNAc modified proteomics on canine osteosarcoma cell lines, including MC control group and shOGT knockdown group with 3 biological replicates per group. TimsTOF Pro mass spectrometry was used to identify differentially O-GlcNAcylated proteins, exploring the regula...
ORGANISM(S): Canis Lupus Familiaris 
PXD079417 |
UnknownHexosamine Biosynthetic Pathway-Derived O-GlcNAcylation Is Critical for RANKL-Mediated Osteoclast Differentiation.
Not available
S-EPMC8396330 | biostudies-literature
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