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TranscriptomicsDynamic Ca2+-dependent transcription links metabolic stress to impaired β-cell identity
Sustained stimulation and elevations in intracellular Ca2+ concentrations due to metabolic stress in pre-diabetic states triggers gene expression changes contributing to the loss of pancreatic β-cell function. To establish a temporal relationship between β-cell stimulation and perturbations in Ca2+...
ORGANISM(S): Mus musculus 
2025-05-22 | E-MTAB-14642 | biostudies-arrayexpress
TranscriptomicsBulk RNAseq of Mus musculus Protein Kinase D1 (Prkd1) knock-out adipose tissue in response to thermoneutral and cold exposure stress
Brown adipose tissue (BAT) has in recent times been rediscovered in adult humans, and together with work from preclinical models, shown to have the potential of providing a variety of positive metabolic benefits. These include improved insulin sensitivity and reduced susceptibility to obesity and it...
ORGANISM(S): Mus musculus 
2023-09-01 | E-MTAB-12170 | biostudies-arrayexpress
TranscriptomicsEffects of the Sox17 ∆50 mutation on SOX17 function in mouse embryonic liver development
To determine the role of specific cis-regulatory elements within the Sox17 endoderm-preferential TSS2 promoter, we generated Sox17∆50 mutant animals and surveyed how this mutation altered Sox17 expression. Livers were isolated from E12.5 Sox17∆50/∆50 and Sox17+/+ embryos (n = 4 of each genotype), R...
ORGANISM(S): Mus musculus 
2024-10-31 | E-MTAB-13982 | biostudies-arrayexpress
TranscriptomicsEffects of the Sox17mut5 mutation on SOX17 function in mouse embryonic gallbladder development
To determine the role of specific cis-regulatory elements within the Sox17 endoderm-preferential TSS2 promoter, we generated Sox17mut5 mutant animals and surveyed how this mutation altered Sox17 expression. Gallbladders were isolated from P21 Sox17mut5/mut5 and Sox17+/+ (n = 4 of each genotype), RN...
ORGANISM(S): Mus musculus 
2024-10-31 | E-MTAB-13978 | biostudies-arrayexpress
TranscriptomicsEffects of the Sox17∆50/GFP mutation on SOX17 function in mouse embryonic liver development
To determine the role of specific cis-regulatory elements within the Sox17 endoderm-preferential TSS2 promoter, we generated Sox17∆50 mutant animals, crossed them to a Sox17GFPCre (a Sox17 null allele), and surveyed how this mutation affected Sox17 expression. Livers were isolated from E12.5 Sox17∆5...
ORGANISM(S): Mus musculus 
2024-10-31 | E-MTAB-13983 | biostudies-arrayexpress
TranscriptomicsRole of Ascl1 in pancreatic beta cell response to metabolic stress
To determine the role of Ascl1 in beta cell development, function, and metabolic stress response, we generated beta cell specific Ascl1 knockout mice and assessed their glucose homeostasis, islet morphology, and gene expression after feeding a normal diet, a high fat diet (HFD) for 12 weeks, or on a...
ORGANISM(S): Mus musculus 
2023-10-05 | E-MTAB-13355 | biostudies-arrayexpress
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