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ProteomicsStructural and functional insights into the Rad51 paralog complexes Shu and Rad55-Rad57 in association with Rad51 in homologous recombination
RAD51 filaments are essential to repair DNA double-strand breaks (DSB) and single-strand DNA (ssDNA) gaps. RAD51 filament formation depends on RAD51 paralogs, but their functions remain unclear. Here, we combined structural modeling and functional analyses to characterize how the yeast Rad51 paralog...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-10-27 | PXD086326 | Pride
Rad51 Dna repair Paralog 
UnknownHeterosis-Based Identification of Candidate Genes Associated with Lipid Metabolism and Meat Quality in Crossbred Pigs.
Not available
S-EPMC12896934 | biostudies-literature
ProteomicsDIA-PASEF analysis of Shu immunoprecipitates from control and Shu knockdown Drosophila OSCs
After control or Shu knockdown (n = 3 each), OSCs were lysed in binding buffer [50 mM Tris-HCl (pH 8.0), 150 mM KOAc, 5 mM Mg(OAc)2, 5 mM DTT, 0.1% NP-40, 2 µg/mL leupeptin, 2 µg/mL pepstatin A, 0.5% aprotinin, 10% glycerol] and centrifuged to remove insoluble debris. The lysates were then incubated...
ORGANISM(S): Drosophila Melanogaster (fruit Fly) 
2026-02-04 | PXD074025 | JPOST Repository
ProteomicsProteomic of Chaihu-Shugan-San (CSS), Rou Gan, and Shu Gan treat chronic unpredictable mild stress (CUMS) rat with Tandem Mass Tags
Chaihu-Shugan-San (CSS) is a classical prescription used to treat depression. According to the traditional Chinese medicine (TCM) principle, the 2 decomposed recipes in CSS exert synergistic effects, including Shu Gan (stagnated Gan-Qi dispersion) and Rou Gan (pain alleviation). However, the specifi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-17 | PXD024436 | Pride
Chaihu-shugan-san Hippocampus Depression Proteomics Traditional chinese medicine 
TranscriptomicsLong non-coding RNAs and mRNAs regulated by TGF-M-NM-2
The role of TGF-M-NM-2-induced epithelial-mesenchymal transition (EMT) in cancer cell dissemination is well established, but the involvement of lncRNAs in TGF-M-NM-2 signaling is still unknown. In this study, we observed that the lncRNA-Activated by TGF-M-NM-2 (lncRNA-ATB) was upregulated in hepatoc...
ORGANISM(S): Homo sapiens 
2014-02-08 | E-GEOD-54797 | biostudies-arrayexpress
ProteomicsProteomics study on caffeine for 10 min
Proteomics study on the HepG2 cells which were treated with 6 doses of caffeine for 10 min
ORGANISM(S): Homo Sapiens 
2022-01-14 | PXD030943 |
UnknownSARS-CoV-2 Membrane Glycoprotein M Triggers Apoptosis With the Assistance of Nucleocapsid Protein N in Cells.
Not available
S-EPMC8425412 | biostudies-literature
ProteomicsEGF promotes PKM2 O-GlcNAcylation by stimulating O-GlcNAc transferase phosphorylation at Y976 and their subsequent association
EGF is one of the most well-characterized growth factors and plays a crucial role in cell proliferation and differentiation. EGFR has been extensively explored as a therapeutic target against multiple types of cancers, such as lung cancer and glioblastoma. Recent studies have established a connectio...
ORGANISM(S): Homo sapiens (Human) 
2022-08-22 | PXD031593 | Pride
Epidermal growth factor (egf) Phosphotyrosine binding protein O-glcnacylation Pyruvate kinase m2 (pkm2) Phosphorylation O-glcnac transferase (ogt) 
TranscriptomicsChromatin immunoprecipitation of Bacillus subtilis to identify Noc protein binding sites
Coordination of chromosome segregation and cytokinesis is crucial for efficient cell proliferation. In Bacillus subtilis the nucleoid occlusion protein Noc protects chromosomes by associating with the chromosome and preventing cell division in its vicinity. Using protein localization, ChAP-on-Chip a...
ORGANISM(S): Bacillus subtilis 
2009-07-01 | E-MEXP-2133 | biostudies-arrayexpress
ProteomicsUncover New Reactivity of Genetically Encoded Alkyl Bromide Unnatural Amino Acids
Genetically encoded unnatural amino acids (Uaas) with electrophilic moieties are excellent tools to investigate protein-protein interactions (PPIs) both in vitro and in vivo. These Uaas, including a series of alkyl bromide-based Uaas, mainly target cysteine residues to form protein-protein cross-lin...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-04-04 | PXD031159 | Pride
Chemical cross-linking And sumo interactome Unnatural amino acid Protein-protein interactions Genetic code expansion 
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