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ProteomicsRibosome heterogeneity in Drosophila melanogaster gonads through paralog-switching
Ribosomes have long been thought of as homogeneous macromolecular machines, but recent evidence suggests they are heterogeneous and could be specialised to regulate translation. Here, we have isolated ribosomal complexes and characterised their protein content across 4 tissues of Drosophila melanoga...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2021-07-22 | PXD026227 | Pride
Gonads Testis Tmt-ms Ribosome Paralog Drosophila melanogaster Ovary 
GenomicsWGD paralog evolution
WGD paralog evolution
PRJNA743682 | ENA
GenomicsSTAT5 paralog dose governs T cell effector and regulatory function
The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remains controversial. We addressed this longstanding question in primary CD4+ 'helper' T cells...
ORGANISM(S): Mus musculus 
2016-03-28 | E-GEOD-77656 | biostudies-arrayexpress
ProteomicsParalog protein compensation preserves protein-protein interaction networks following gene loss cancer
Abstract Proteins operate within dense interconnected networks, where interactions are necessary both for stabilising proteins and enabling them to execute their molecular functions. Remarkably, the protein-protein interaction networks operating within tumour cells continue to function despite wide...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055643 | Pride
Protein-protein interaction Compensation Paralog protein Cancer. 
ProteomicsConserved exchange of paralog proteins during neuronal differentiation
Gene duplication enables the emergence of new functions by lowering the general evolutionary pressure. Previous studies have highlighted the role of specific paralog genes during cell differentiation, e.g., in chromatin remodeling complexes. It remains unexplored whether similar mechanisms extend to...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-07 | PXD027387 | Pride
Development Protein complex Transport Paralog Proteome Neuronal differentiation 
TranscriptomicsNrf2b: a novel zebrafish paralog of the oxidant-responsive transcription factor Nrf2.
We identified a novel paralog of the antioxidant response element transcription factor, Nrf2 in zebrafish. To determine whether the paralogs Nrf2a and Nrf2b regulate different sets of genes, we performed loss-of-function experiments followed by microarray-based gene expression profiling, performed ...
ORGANISM(S): Danio rerio 
2011-12-20 | E-GEOD-32594 | biostudies-arrayexpress
GenomicsIncomplete paralog compensation generates selective dependency on TRA2A in cancer
Incomplete paralog compensation generates selective dependency on TRA2A in cancer
PRJNA1251972 | ENA
TranscriptomicsParalog Specificity in cDNA Microarray Experiments
cDNA microarrays have become the technology of choice for profiling the expression of thousands of genes simultaneously in a single sample. However, cross-hybridization between targets and probes that do not correspond must be considered carefully during the design, analysis, and interpretation of t...
ORGANISM(S): Haplochromis burtoni 
2010-05-16 | E-GEOD-16939 | biostudies-arrayexpress
ProteomicsConserved exchange of paralog proteins during neuronal differentiation
Gene duplication enables the emergence of new functions by lowering the general evolutionary pressure. Previous studies have highlighted the role of specific paralog genes during cell differentiation, e.g., in chromatin remodeling complexes. It remains unexplored whether similar mechanisms extend to...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2022-03-07 | PXD027191 | Pride
Neuronal differentiation Protein complexes Paralogs 
ProteomicsConserved exchange of paralog proteins during neuronal differentiation
Gene duplication enables the emergence of new functions by lowering the general evolutionary pressure. Previous studies have highlighted the role of specific paralog genes during cell differentiation, e.g., in chromatin remodeling complexes. It remains unexplored whether similar mechanisms extend to...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-07 | PXD027195 | Pride
Neuronal differentiation Protein complexes Mouse Paralogs 
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