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TranscriptomicsDisruption of transkingdom communication by antibiotics leads to immune and mitochondrial dysfunction in the gut
We analyzed the effects of antibiotics using a popular model of gut microbiota depletion in mice by a cocktail of antibiotics. We combined intestinal transcriptome together with metagenomic analysis of the gut microbiota to develop a new bioinformatics approach that probes the links between microbia...
ORGANISM(S): Mus musculus 
2015-01-26 | E-GEOD-60568 | biostudies-arrayexpress
TranscriptomicsCrosstalk between B lymphocytes, microbiota and the intestinal epithelium governs immunity versus metabolism in the gut
This SuperSeries is composed of the following subset Series: GSE23573: B-cell KO mice data GSE23933: human duodenum biopsy data GSE33884: The role of immunoglobulin A GSE33885: The role of transcription factor Gata4 Refer to individual Series
ORGANISM(S): Mus musculus 
2011-11-15 | E-GEOD-23934 | biostudies-arrayexpress
Genomics
Host response to cholestyramine can be mediated by the gut microbiota
PRJNA686421 | ENA
TranscriptomicsDisruption of transkingdom communication by antibiotics leads to immune and mitochondrial dysfunction in the gut (main)
We analyzed the effects of antibiotics using a popular model of gut microbiota depletion in mice by a cocktail of antibiotics. We combined intestinal transcriptome together with metagenomic analysis of the gut microbiota to develop a new bioinformatics approach that probes the links between microbia...
ORGANISM(S): Mus musculus 
2015-01-26 | E-GEOD-60566 | biostudies-arrayexpress
TranscriptomicsDisruption of transkingdom communication by antibiotics leads to immune and mitochondrial dysfunction in the gut (LMD)
We analyzed the effects of antibiotics using a popular model of gut microbiota depletion in mice by a cocktail of antibiotics. We combined intestinal transcriptome together with metagenomic analysis of the gut microbiota to develop a new bioinformatics approach that probes the links between microbia...
ORGANISM(S): Mus musculus 
2015-01-26 | E-GEOD-60567 | biostudies-arrayexpress
Transcriptomicshuman duodenum biopsy data
Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium, and the microbiota. We found that mice lacking B lymphocytes, or lacking IgA, have low intestinal expression of lipid metabolism genes regulated by the transcri...
ORGANISM(S): Homo sapiens 
2011-11-15 | E-GEOD-23933 | biostudies-arrayexpress
TranscriptomicsThe role of transcription factor Gata4
Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium, and the microbiota. We found that mice lacking B lymphocytes, or lacking IgA, have low intestinal expression of lipid metabolism genes regulated by the transcri...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-33885 | biostudies-arrayexpress
TranscriptomicsB-cell KO mice data
Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium, and the microbiota. We found that mice lacking B lymphocytes, or lacking IgA, have low intestinal expression of lipid metabolism genes regulated by the transcri...
ORGANISM(S): Mus musculus 
2011-11-15 | E-GEOD-23573 | biostudies-arrayexpress
TranscriptomicsThe role of immunoglobulin A
Using a systems biology approach, we discovered and dissected a three-way interaction between the immune system, the intestinal epithelium, and the microbiota. We found that mice lacking B lymphocytes, or lacking IgA, have low intestinal expression of lipid metabolism genes regulated by the transcri...
ORGANISM(S): Mus musculus 
2011-11-23 | E-GEOD-33884 | biostudies-arrayexpress
TranscriptomicsEffect of interferon-gamma (IFNg) deficiency in murine small intestine (ileum)
Gene expression profiling of C57Bl/6 wild type and IFNg-deficient whole ileum at 8 weeks of age 5 wild type control, 5 IFNg knockout
ORGANISM(S): Mus musculus 
2016-07-16 | E-GEOD-69635 | biostudies-arrayexpress
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