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ProteomicsRNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway
mRNA level is controlled by factors that mediate both mRNA synthesis and decay, including the 5’ to 3’ exonuclease Xrn1 - a major mRNA synthesis and decay factor. Here we show that nucleocytoplasmic shuttling of several mRNA decay factors plays a key role in determining both mRNA synthesis and decay...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-09-19 | PXD036414 | Pride
Nucleocytoplasmic shuttling Xrn1 Mrna decay 
TranscriptomicsNucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer
Biological oscillations are observed at many levels of cellular organization. In the social amoebae Dictyostelium discoideum, starvation-triggered multicellular development is organized by periodic cAMP waves, which provide both chemoattractant gradients and developmental signals. We report that Gta...
ORGANISM(S): Dictyostelium discoideum 
2014-04-15 | E-GEOD-54866 | biostudies-arrayexpress
TranscriptomicsNucleocytoplasmic shuttling of a GATA transcription factor functions as a development timer
Biological oscillations are observed at many levels of cellular organization. In the social amoebae Dictyostelium discoideum, starvation-triggered multicellular development is organized by periodic cAMP waves, which provide both chemoattractant gradients and developmental signals. We report that Gta...
ORGANISM(S): Dictyostelium discoideum 
2014-04-15 | GSE54866 | GEO
UnknownInterrelation between α-Cardiac Actin Treadmilling and Myocardin-Related Transcription Factor-A Nuclear Shuttling in Cardiomyocytes.
Not available
S-EPMC9266856 | biostudies-literature
UnknownNucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function.
Not available
S-EPMC8352595 | biostudies-literature
ProteomicsTranslational activity of the splicing factor SRSF1 is required for development and cilia function
The SR protein family of splicing factors regulate constitutive and alternative pre-mRNA splicing. A subset of them, including SRSF1, shuttles continuously between the nucleus and cytoplasm affecting post-splicing processes. We have previously identified a role for SRSF1 in promoting the translation...
ORGANISM(S): Mus musculus (Mouse) 
2021-08-06 | PXD019859 | Pride
Sr proteins/ srsf1/ mrna translation/ alternative splicing/ cilia 
UnknownNucleocytoplasmic shuttling of Gle1 impacts DDX1 at transcription termination sites.
Not available
S-EPMC7851961 | biostudies-literature
ProteomicsBidirectional substrate shuttling between the 26S proteasome and the Cdc48 ATPase promotes protein degradation
Most eukaryotic proteins are degraded by the 26S proteasome after modification with a polyubiquitin chain. Substrates lacking unstructured segments cannot be degraded directly and require prior unfolding by the Cdc48 ATPase (p97 or VCP in mammals) in complex with its ubiquitin-binding partner Ufd1-N...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-02-23 | PXD042878 | Pride
Erad Aaa atpase Protein degradation Ubiquitin Cdc48 Shuttling factor P97 Proteasome Protein unfolding 
UnknownAn essential role for hGle1 nucleocytoplasmic shuttling in mRNA export.
Not available
S-EPMC2172758 | biostudies-literature
UnknownMice develop normally in the absence of Smad4 nucleocytoplasmic shuttling.
Not available
S-EPMC1868808 | biostudies-literature
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