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ProteomicsWhole proteome and Secretome analysis of Staphylococcus aureus ClpXP mutant strains
Staphylococcus aureus represents an opportunistic pathogen which utilizes elaborate quorum sensing mechanisms to precisely control the expression and secretion of virulence factors. Previous studies indicated a role of the ClpXP proteolytic system in controlling pathogenesis. While detailed transcri...
ORGANISM(S): Bacteria Staphylococcus aureus 
2021-03-12 | PXD018932 | Pride
Proteomics Staphylococcus aureus Whole proteome analysis Lc-ms/ms 
ProteomicsThe cytotoxic natural product vioprolide A targets nucleolar protein 14 essential for ribosome biogenesis
The cytotoxic and antifungal peptolides vioprolide A-D were discovered in 1996, however their mode-of-action has so far been unsolved. Anti-cancer effect of the most potent cytotoxic derivative vioprolide A (VioA) were evaluated, showing a prominent potency against human acute lymphoblastic leukemia...
ORGANISM(S): Homo sapiens (Human) 
2020-01-13 | PXD015196 | Pride
Natural product Afbpp Lc-ms Target identification Thermal proteome profiling Co-ip 
TranscriptomicsTranscriptome sequencing and comparative transcriptome analysis of the scleroglucan producer Sclerotium rolfsii
Two S. rolfsii transcriptomes obtained from scleroglucan-producing and scleroglucan-nonproducing conditions were pooled and sequenced using the 454 pyrosequencing technique yielding ~350,000 reads. These could be assembled into 21,937 contigs and 171,833 singletons, for which 6,951 had significant m...
ORGANISM(S): Athelia rolfsii 
2010-05-15 | E-GEOD-21040 | biostudies-arrayexpress
TranscriptomicsRobust Molecular Classification of Ependymal Tumors Across All Anatomic Compartments
Ependymal tumors across age groups have been classified solely by histopathology. It is, however, commonly accepted that this classification has limited clinical utility based on its poor reliability. We aimed at establishing a reliable and reproducible molecular classification using DNA methylation...
ORGANISM(S): Homo sapiens 
2015-05-21 | E-GEOD-65362 | biostudies-arrayexpress
TranscriptomicsMethylation profiling data from medulloblastoma tumor samples
Smoothened (SMO)-inhibitors recently entered clinical trials for sonic-hedgehog driven medulloblastoma (SHH-MB). Clinical response appears highly variable. To understand the mechanism(s) of primary resistance and to identify pathways co-operating with aberrant SHH-signaling, we sequenced a large coh...
ORGANISM(S): Homo sapiens 
2014-09-02 | E-GEOD-49377 | biostudies-arrayexpress
Genomicsena-DATASET-DKFZ-IBIOS-24-09-2015-14:57:59:343-450 - samples
release_2: ICGC PedBrain: whole exome sequencing and Target-Seq
EGAD00001001624 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-24-09-2015-12:58:34:639-433 - samples
release_2: ICGC PedBrain: RNA sequencing
EGAD00001001620 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-25-01-2016-08:42:37:641-84 - samples
Whole genome bisulfite sequencing of pedbrain - medulloblastoma
EGAD00001001891 | EGA
Genomicsena-DATASET-DKFZ-IBIOS-03-12-2015-09:19:32:271-3 - samples
4C-seq data was generated for regions of interest to confirm enhancer-gene promoter interactions
EGAD00001001847 | EGA
GenomicsRNA-seq_DATA_SET_ICGC_PedBrainTumor_Medulloblastoma_Discovery_Cohort - samples
ICGC PedBrain: RNA sequencing
EGAD00001000328 | EGA
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