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TranscriptomicsRegulation of Transcription Termination by Glucosylated Hydroxymethyluracil, Base J, in L. major and T. brucei
Base J, β-D-glucosyl-hydroxymethyluracil, is an epigenetic modification of thymine in the nuclear DNA of flagellated protozoa of the order Kinetoplastida. J is enriched at sites involved in RNA Polymerase (RNAP) II initiation and termination. We have previously demonstrated a role of J in regulating...
ORGANISM(S): Trypanosoma brucei 
2015-05-18 | E-GEOD-57621 | biostudies-arrayexpress
TranscriptomicsBase J represses genes at the end of polycistronic gene clusters in Leishmania major by promoting RNAP II termination
Base J and H3.V promote RNA Polymerase (RNAP) II termination within polycistronic gene clusters in the kinetoplastid species Trypanosoma brucei. Although base J has been shown to promote RNAP II termination in the related kinetoplastid species Leishmania major and Leishmania tarentolae, the role of ...
ORGANISM(S): Leishmania major 
2016-07-20 | E-GEOD-77632 | biostudies-arrayexpress
UnknownSWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Not available
S-EPMC4534524 | biostudies-literature
ProteomicsPresentation of the Extra-Cellular Domain of the Sars2 Spike Glycoprotein by Immunopeptidomic Profiling of HLA-II Bound Peptides from Human Dendritic Cells
In the present study we sought to identify the naturally processed and presented immunopeptidome of the SARS-CoV-2 spike glycoprotein from human antigen presenting cells. Monocyte-derived dendritic cells from a panel of healthy human subjects representing a majority of the HLA-DRB1 allele usage with...
ORGANISM(S): Sars Coronavirus (ncbitaxon:227859) Bos (ncbitaxon:9903) Homo Sapiens (ncbitaxon:9606) 
2020-05-21 | MSV000085456 | MassIVE
UnknownHealth-Related Quality-of-Life Results From the Open-Label, Randomized, Phase III ASPIRE Trial Evaluating Carfilzomib, Lenalidomide, and Dexamethasone Versus Lenalidomide and Dexamethasone in Patients With Relapsed Multiple Myeloma.
Not available
S-EPMC5791840 | biostudies-literature
MetabolomicsPRDM15 is a master regulator of metabolism essential to sustain B-cell lymphomagenesis
PRDM family members are sequence-specific transcriptional regulators involved in cell identity and fate determination and are often dysregulated in cancer. The PRDM15 gene is of particular interest, given its relatively low expression in adult tissues and its overexpression in follicular lymphomas (...
2025-06-16 | MTBLS1639 | MetaboLights
TranscriptomicsHistone variant 3 regulates RNA polymerase II transcription termination and dual strand transcription of siRNA loci in Trypanosoma brucei
Histone variant 3 (H3V) is a kinetoplastid specific histone variant that is enriched at RNA polymerase II termination sites and telomeres. We previously found that the DNA modification base J, which co-localizes with H3V, functions to prevent readthrough transcription within gene clusters in T. bruc...
ORGANISM(S): Trypanosoma brucei 
2016-06-30 | E-GEOD-70229 | biostudies-arrayexpress
UnknownA novel multiple biomarker panel for the early detection of high-grade serous ovarian carcinoma.
Not available
S-EPMC5986604 | biostudies-literature
UnknownResults of the two incidence screenings in the National Lung Screening Trial.
Not available
S-EPMC4307922 | biostudies-literature
UnknownReduced lung-cancer mortality with low-dose computed tomographic screening.
Not available
S-EPMC4356534 | biostudies-literature
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