Acquisition of a new strain of non-typeable Haemophilus influenzae (NTHi) is often associated with exacerbation of chronic obstructive pulmonary disease (COPD). We have previously reported that COPD patients who are homozygous null for SIGLEC14 gene is less susceptible to COPD exacerbation than thos...
Proteins that interact with Siglec-14 were identified by proximity labeling, followed by streptavidin affinity purification and proteomic analysis. MaxQuant software was used for the quantitative analysis of the proteins identified.
Influence of soluble Siglec-14 on macrophage poloarization was examined by analyzing the transcripts from human macrophages cultured in the presence or absence of recombinant soluble Siglec-14 protein
