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MetabolomicsPrediction of complex phenotypes using the Drosophila melanogaster metabolome
Understanding the genotype-phenotype map and how variation at different levels of biological organization is associated are central topics in modern biology. Fast developments in sequencing technologies and other molecular omic tools enable researchers to obtain detailed information on variation at ...
2021-08-05 | MTBLS2060 | MetaboLights
ProteomicsStructure of the human signal peptidase complex
The ER-resident signal peptidase complex (SPC) is an essential membrane protein complex involved in the maturation of soluble and type-I transmembrane proteins destined to the secretory pathway. As a part of the ER translocon machinery, the SPC removes signal peptides (SPs) from the N-termini of man...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2021-07-05 | PXD022002 | Pride
Crosslinking ms Signal peptidase complex Cryoem 
TranscriptomicsTranslocase malfunction causes extracellular protein translocation stress ( EPTS) in Streptomyces lividans
The genomic and proteomic analyses of Streptomyces lividans strains deficient in the major signal peptidase SipY or in the translocase complex protein SecG resulted in a set of genes being equally regulated. These genes are apparently responsible for the common deficiencies in extracellular protein ...
ORGANISM(S): Streptomyces lividans 
2012-05-03 | E-GEOD-17012 | biostudies-arrayexpress
GenomicsCleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signalling pathway
Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signalling pathway
PRJNA906580 | ENA
ProteomicsProximity-dependent biotinylation reveals an interaction between ubiquitin-specific peptidase 46 and centrosome-related proteins
To characterize the protein interaction network of USP46, BioID analysis was conducted on a knock-in cell line that expresses USP46 and biotin ligase fusion protein stably.
ORGANISM(S): Mus Musculus (mouse) 
2025-03-25 | PXD053674 | JPOST Repository
TranscriptomicsCleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signalling pathway
iRhoms are pseudoprotease members of the rhomboid-like superfamily and are cardinal regulators of inflammatory and growth factor signaling; they function primarily by recognizing transmembrane domains of their clients. Here, we report a mechanistically distinct nuclear function of iRhoms, showing th...
ORGANISM(S): Homo sapiens 
2024-01-04 | GSE219008 | GEO
TranscriptomicsThe Streptomyces lividans lsp mutant
The Streptomyces lividans lsp gene encodes a type II signal peptidase (Lsp) that cleaves the type II leader peptides of lipoproteins. Transcriptional profiling of the bacterium depleted of the lsp gene mainly resulted in deactivation of the sigma U regulon, as well as in downregulation of genes invo...
ORGANISM(S): Streptomyces lividans 
2014-05-22 | E-GEOD-30728 | biostudies-arrayexpress
ProteomicsSpc2 modulates substrate- and cleavage site-selection in the yeast signal peptidase complex
LC-MS/MS data associated with: "Yeonji Chung, Chewon Yim, Gilberto P. Pereira, Sungjoon Son, Lisbeth R. Kjoelbye, Lauren E. Mazurkiewicz, Amy M. Weeks, Friedrich Foerster, Gunnar von Heijne, Paulo C.T. Souza, Hyun Kim; Spc2 modulates substrate- and cleavage site-selection in the yeast signal peptida...
ORGANISM(S): Saccharomyces Cerevisiae (ncbitaxon:4932) 
2025-08-05 | MSV000098726 | MassIVE
UnknownBunyamwera orthobunyavirus glycoprotein precursor is processed by cellular signal peptidase and signal peptide peptidase.
Not available
S-EPMC4978261 | biostudies-literature
UnknownSignal peptidase complex mediates rotavirus VP7 processing and virion assembly.
Not available
S-EPMC12637713 | biostudies-literature
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