Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

Lung cancer (LC) is still one of the most deadly cancers in the world, but there is a lack of non-invasive biomarkers to assist diagnosis and guide treatment. Herein, untargeted serum metabolomics of 57 LC patients and 59 HC people was performed based on gas chromatography-mass spectrography (GC-...

Acute lung injury (ALI) is a lung disease characterized by an excessive inflammatory response and damage to lung epithelial cells. Atractylodin (ATL) is the main active component of Atractylodes lancea (Thunb.) DC., which has good anti-inflammatory activity and protects the integrity of the epith...

BACKGROUND: Perioperative neurocognitive disorder (PND) is a key complication affecting older individuals after anesthesia and surgery. Failure to translate multiple pharmacological therapies for PND from preclinical studies to clinical settings has necessitated the exploration o...

Plants integrate light signals to regulate development and produce protective compounds such as flavonoids under excessive light stress. While these metabolites protect against light damage, their roles in modulating photoreceptor responses remain unclear. Here we show that naringenin chalcone (N...

Recovery from acute pancreatitis (AP) involves complex biological processes, and the mechanisms governing pancreatic repair remain unclear. In a clinical cohort during the recovery phase of AP, impaired pancreatic recovery was associated with intestinal dysbiosis, depletion of the microbial bile ...

This analysis established comprehensive metabolomic profiles of adenomyosis patients and revealed widespread alterations in the metabolome within normal and fibrotic myometrium. Integrated analysis shown significant associations between metabolomic data and fibrosis . This study is the first to d...

BACKGROUND: Painful diabetic neuropathy (PDN) is characterized by hyperalgesia and neuronal hyperexcitability. Although gut microbiota dysbiosis have been found in PDN, how microbiota influences PDN remains largely unexplored. RESULTS: Gut microbiota and its metabolites impacted PDN was investiga...

Background Both high fiber diet and N-Carbamylglutamate (NCG) individually contributes to improve reproductive efficiency in sow. However, the potential synergistic effects and the underlying mechanisms are not well-understood. Here, Landrace x Yorkshire sows were selected to investigate the syne...