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MetabolomicsMultiomics of synaptic junctions reveals altered lipid metabolism and signaling following environmental enrichment
Membrane lipids and their metabolism have key functions in neurotransmission. Here we provide a quantitative lipid inventory of mouse and rat synaptic junctions. To this end, we developed a multiomics extraction and analysis workflow to probe the interplay of proteins and lipids in synaptic signal t...
2021-09-27 | MTBLS1531 | MetaboLights
TranscriptomicsEffect of NJ15 on gene expression profiles in Arabidopsis thaliana seedlings
Brassinosteroid (BR) and auxin co-regulate plant growth in a process termed cross-talking. Based on the assumption that their signal transductions are partially shared, inhibitory chemicals for both signal transductions were screened from a commercially-available library. A chemical designated as NJ...
ORGANISM(S): Arabidopsis thaliana 
2014-11-03 | E-GEOD-57449 | biostudies-arrayexpress
ProteomicsStructural Analysis of Hippocampal Kinase Signal Transduction
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolu...
ORGANISM(S): Rattus Norvegicus (ncbitaxon:10116) 
2018-05-23 | MSV000082390 | MassIVE
ProteomicsDynamic phosphoproteomics of BRS3 activation reveals Hippo signaling pathway for cell migration
Bombesin receptor subtype-3 (BRS3) is an orphan G-protein coupled receptor (GPCR) that involved in a range of pathological and physiological processes, while its biological functions and underlying regulatory mechanisms remain largely unknown. Quantitative phosphoproteomics approach was employed in ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-12 | PXD035666 | Pride
Phosphoproteomics Hippo signaling pathway Signaling transductions Gpcr Cell migration 
TranscriptomicsIdentification of immediate early transcriptional targets of ephrin-B1 forward signaling
The goal of this study was to identify immediate early transcriptional targets of ephrin-B1 forward signaling that are relevant to palatogenesis. The Ephs compose a family of receptor tyrosine kinase signaling molecules that can be activated by their cognate ligands, the ephrins. Despite the import...
ORGANISM(S): Mus musculus 
2010-09-20 | E-GEOD-23539 | biostudies-arrayexpress
TranscriptomicsCUT&RUN sequencing of human kidney tubuloid to study genome-wide binding site in tRCC patients
Translocation renal cell carcinoma (tRCC) is a rare, aggressive kidney cancer primarily occurring in children. They are genetically defined by translocations involving MiT/TFE gene family members, TFE3. We utilized human kidney organoids, or tubuloids, to engineer a tRCC model by expressing of one o...
ORGANISM(S): Homo sapiens 
2024-10-01 | E-MTAB-13900 | biostudies-arrayexpress
TranscriptomicsMitochondrial two-component signaling systems in Candida albicans
Two-component signal transduction pathways are one of the primary means by which microorganisms respond to environmental signals. These signaling cascades originated in prokaryotes and were inherited by eukaryotes via endosymbiotic lateral gene transfer from ancestral cyanobacteria. We report here t...
ORGANISM(S): Candida albicans 
2013-07-02 | E-GEOD-45438 | biostudies-arrayexpress
TranscriptomicsInterbacterial signaling via Burkholderia contact-dependent growth inhibition proteins
In prokaryotes and eukaryotes, cell-cell communication and recognition of self are critical to coordinate multicellular functions. While kin and kind discrimination are increasingly appreciated to shape naturally occurring microbe populations, the underlying mechanisms that govern these interbacteri...
ORGANISM(S): Burkholderia thailandensis 
2016-08-09 | E-GEOD-83143 | biostudies-arrayexpress
TranscriptomicsTLR 4 Signaling Inhibitory Pathway Induced by Green Tea Polyphenol Epigallocatechin-3-Gallate through 67-kDa Laminin Receptor
Epigallocatechin-3-gallate (EGCG), a major active polyphenol of green tea, has been shown to downregulate inflammatory responses in macrophages; however, the underlying mechanism has not been understood. Recently, we identified the 67-kDa laminin receptor (67LR) as a cell-surface EGCG receptor that ...
ORGANISM(S): Mus musculus 
2010-04-20 | E-GEOD-21320 | biostudies-arrayexpress
TranscriptomicsExpression data from insulin-treated human primary fibroblasts and effects of U0126 on insulin-induced gene expression
We carried out a high throughput analysis of insulin-induced kinase signaling pathways in primary fibroblasts from 35 unrelated individuals. We found that extensive individual variation exists in induction of various signaling pathways. ERK signaling displayed the greatest variation, which led to ...
ORGANISM(S): Homo sapiens 
2015-08-03 | E-GEOD-21891 | biostudies-arrayexpress
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