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MetabolomicsMetabolomics revealed the influence of breast cancer on lymphatic endothelial cell metabolism, metabolic crosstalk, and lymphangiogenic signaling in co-culture

Breast cancer metastasis occurs via blood and lymphatic vessels. Breast cancer cells 'educate' lymphatic endothelial cells (LECs) to support tumor vascularization and growth. However, despite known metabolic alterations in breast cancer, it remains unclear how lymphatic endothelial cell metabolis...

2024-06-25 | MTBLS859 | MetaboLights
MetabolomicsThe Crosstalk between Microbiota and Metabolites in AP Mice Based on Metagenomics and Untargeted Metabolomics

BACKGROUND AND PURPOSE: The microbiota dysfunction aggravated the severity of acute pancreatitis (AP), but the relationship between microbiota dysfunction and metabolites alteration was not fully explained. This study aimed to explore the crosstalk between microbiota and metaboli...

2023-08-10 | MTBLS6831 | MetaboLights
MetabolomicsMulti-omics analysis reveals microbiota-metabolite crosstalk in MASLD pathogenesis in a non-obese murine model

The rising global prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD), including its severe form metabolic dysfunction-associated steatohepatitis (MASH), underscores the urgency to elucidate its pathophysiology. To investigate key metabolic interactions central to MASLD...

2026-03-13 | MTBLS14048 | MetaboLights
UnknownRal-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling.
Not available
S-EPMC4973806 | biostudies-literature
TranscriptomicsGenomics of signalling crosstalk of estrogen receptor alpha in breast cancer cells
The estrogen receptor a (ERa) is a ligand-regulated transcription factor. However, a wide variety of other extracellular signals can activate ERa in the absence of estrogen. The impact of these alternate modes of activation on gene expression profiles has not been characterized. We show that estroge...
ORGANISM(S): Homo sapiens 
2008-05-22 | E-GEOD-10466 | biostudies-arrayexpress
ProteomicsA positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signaling in Toxoplasma gondii.
Fundamental processes of obligate intracellular parasites, such as Plasmodium falciparum and Toxoplasma gondii are controlled by a set of plant-like calcium dependent kinases (CDPKs), the conserved cAMP- and cGMP-dependent protein kinases (PKA and PKG), second messengers and lipid signalling. While ...
ORGANISM(S): Homo sapiens (Human) Toxoplasma gondii RH 
2022-10-17 | PXD030057 | Pride
Toxoplasma gondii Calcium-signalling Egress Cdpk3 
TranscriptomicsCrosstalk between two bZIP signaling pathways orchestrates salt-induced metabolic reprogramming in Arabidopsis roots
Soil salinity increasingly causes crop losses worldwide. Although roots are the primary targets of salt stress, the signaling networks that facilitate metabolic reprogramming to induce stress tolerance are less understood than those in leaves. Here, a combination of transcriptomic and metabolic appr...
ORGANISM(S): Arabidopsis thaliana 
2015-09-02 | E-GEOD-71001 | biostudies-arrayexpress
ModelsQi2013 - IL-6 and IFN crosstalk model
Qi2013 - IL-6 and IFN crosstalk model This model [BIOMD0000000544] describes the crosstalk between IFN-gamma and IL-6 induced signalling; it aims to outline mechanisms and factors that may control the interaction between both signalling pathways, discussing a role of heterodimer formation in signa...
2024-09-02 | BIOMD0000000544 | BioModels
ModelsQi2013 - IL-6 and IFN crosstalk model (non-competitive)
Qi2013 - IL-6 and IFN crosstalk model (non-competitive) This model [BIOMD0000000543] describes the crosstalk between IFN-gamma and IL-6 induced signalling; it aims to outline mechanisms and factors that may control the interaction between both signalling pathways, discussing a role of heterodimer f...
2024-09-02 | BIOMD0000000543 | BioModels
ProteomicsCrosstalk with lung fibroblasts shapes the growth and therapeutic response of mesothelioma cells
Mesothelioma is an aggressive cancer of the mesothelial layer associated with an extensive fibrotic response. The latter is in large part mediated by cancer-associated fibroblasts which mediate tumour progression and poor prognosis. However, understanding of the crosstalk between cancer cells and fi...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD040492 | Pride
Mesothelioma Cancer associated fibroblast Signalling crosstalk Targeted therapy 
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