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TranscriptomicsSilica nanoparticles effects on gene expression of A549 cells
Expansion of nanotechnology will bring many potential benefits as adversely effects on human health. Protection of the human respiratory system from exposure of volatile nanoparticles has become an emerging health concern. The understanding of the biological processes involved in the development and...
ORGANISM(S): Homo sapiens 
2014-09-08 | E-GEOD-53700 | biostudies-arrayexpress
TranscriptomicsExpression data from human lung epithelial cells after amorphous silica nanoparticle exposure for 40 passages
Amorphous silica nanoparticles induce malignant transformation and tumorigenesis of human lung epithelial cells. We used microarrays to detail the global programme of gene expression underlying the cellular malignant transformation induced by amorphous silica nanoparticles and identified distinct cl...
ORGANISM(S): Homo sapiens 
2016-06-01 | E-GEOD-82062 | biostudies-arrayexpress
GenomicsTargeting somatostatin receptors by functionalized mesoporous silica nanoparticles.
Targeting somatostatin receptors by functionalized mesoporous silica nanoparticles.
PRJEB23155 | ENA
ProteomicsIntegrative metabolomics, proteomics and transcriptomics analysis reveals liver toxicity of mesoporous silica nanoparticles
As pharmaceutical excipients, mesoporous silica nanoparticles (MSNs) have attracted considerable concern based on potential risks to the public. The impact of MSNs on biochemical metabolism is poorly understood, and few studies have compared the effects of MSNs administered via different routes. To ...
ORGANISM(S): Mus musculus (Mouse) 
2022-01-06 | PXD030757 | Pride
Proteomics Mesoporous silica nanoparticle Metabolomics Hepatotoxicity Inflammation Transcriptomic Oxidative stress Oxidative phosphorylation. 
ProteomicsMesoporous Silica Nanoparticles-based Formulations for Enhanced Oral Delivery of Peptide Drugs: a Case Study on Insulin
Peptide drugs have revolutionized modern medicine owing to their high potency, selectivity, and excellent tolerability. However, oral delivery remains limited, and most peptide drugs are administered parenterally due to their inherent instability to proteolytic digestion and poor ability to cross ga...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD074176 | Pride
Mesoporous silica nanoparticles (msn)  peptide delivery  peptide drugs  proteomics Insulin 
GenomicsRNAseq analysis of silica coated magnetic nanoparticles treated BV2 cells
RNAseq analysis of silica coated magnetic nanoparticles treated BV2 cells
PRJNA645589 | ENA
ProteomicsAmorphous silica nanoparticle exposures can lead to mitochondrial protein changes
Mitochondrial fractions from J774 mouse macrophage/monocyte cells were exposed to amorphous silica nanoforms and mitochondrial protein profiles were examined to gain information on relative toxicities of these nanomaterials on mitochondrial pathways and identify potency determinants, for risk charac...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-22 | PXD027593 | Pride
Proteomics Mass spectrometry Exposure Physicochemical characteristics Mitochondria Amorphous silica nanomaterials Nanoforms 
TranscriptomicsDose dependent toxicological response of lung cells exposed to silica nanoparticles
We have employed whole genome microarray expression to distinguish the effect of Fumed Silica Nanoparticles on human alveolar epithelial A549 lung cells. Cells were exposed in vitro, and datasets of differentially expressed genes were identified for NPs versus control samples. NPs induced gene expre...
ORGANISM(S): Homo sapiens 
2015-03-01 | E-GEOD-63806 | biostudies-arrayexpress
TranscriptomicsRNAseq analysis of silica coated magnetic nanoparticles treated BV2 cells
We report the gene expression profile in BV2 murine microglia cell line after treatment of silica coated magnetic nanoparticles with low dose (0.01 µg/µl) and high dose (0.1 µg/µl) for 12 h.
ORGANISM(S): Mus musculus 
2021-08-18 | GSE154250 | GEO
TranscriptomicsDose dependent toxicological response of lung cells exposed to silica nanoparticles
We have employed whole genome microarray expression to distinguish the effect of Fumed Silica Nanoparticles on human alveolar epithelial A549 lung cells. Cells were exposed in vitro, and datasets of differentially expressed genes were identified for NPs versus control samples.
ORGANISM(S): Homo sapiens 
2015-03-01 | GSE63806 | GEO
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