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MetabolomicsEpithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic
Immunity to intestinal helminth infections has been well studied, but the mechanism of helminth killing prior to expulsion remains unclear. Here we identify epithelial-cell-derived phospholipase A2 group 1B (PLA2g1B) as a host-derived endogenous anthelmintic. PLA2g1B is elevated in resistant mice an...
2018-08-13 | MTBLS523 | MetaboLights
TranscriptomicsThe IHF regulon of exponentially growing Pseudomonas putida cells
Integration host factor (IHF) sites are largely absent from intergenic regions of ORFs encoding central metabolic functions in Pseudomonas putida mt-2. To gain an insight into this unequal distribution of otherwise abundant IHF-binding sequences, the transcriptome of IHF-plus and IHF-minus cells gro...
ORGANISM(S): Pseudomonas putida 
2012-07-24 | E-GEOD-23499 | biostudies-arrayexpress
GenomicsTranscriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming (ChIP-seq)
Reactivation of the pluripotency network during somatic cell reprogramming by exogenous transcription factors involves chromatin remodeling and the recruitment of RNA polymerase II (Pol II) to target loci. Here, we report that Pol II is engaged at pluripotency promoters in reprogramming but remains ...
ORGANISM(S): Mus musculus 
2014-10-07 | E-GEOD-59828 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of P. yoelii SAP1 knockout
To study the function of gene SAP1. We knocked out SAP1 gene in P. yoelii, and compared the global gene expression profiles of the P. yoelii SAP1 knockout parasites isolated from mosquito salivary gland to that of wild type P. yoelii parasites. RNA samples from SAP1 knock out (SAP1ko) were directly ...
ORGANISM(S): Plasmodium yoelii 
2010-05-15 | E-GEOD-12397 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of an azole-resistant Candida parapsilosis isolate [posaconazole].
Azole resistance was induced in vitro by growth of a susceptible C. parapsilosis isolate in the presence of posaconazole. Whole genome microarrays were used to compare the transcriptional response of the posaconazole-resistant and susceptible isolates. Transcriptional profile of an in vitro derived ...
ORGANISM(S): Candida parapsilosis 
2011-04-18 | E-GEOD-27407 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis
Purpose: to evaluate changes in the transcriptome of hippocampal cells during the course of epileptogenesis, from the early events post status epilepticus (SE) to the onset of recurrent spontaneous seizures. Experimental Design: Gene expression profiling was analyzed in hippocampi of rats subjected ...
ORGANISM(S): Rattus norvegicus 
2010-02-09 | E-GEOD-14763 | biostudies-arrayexpress
TranscriptomicsHigh-resolution analysis of the m-xylene/toluene biodegradation subtranscriptome of Pseudomonas putida mt-2 [RNA-seq]
Pseudomonas putida mt-2 metabolizes m-xylene and other aromatic compounds through the enzymes encoded by the xyl operons of the TOL plasmid pWW0 along with other chromosomally-encoded activities. Tiling arrays of densely overlapping oligonucleotides were designed to cover every gene involved in this...
ORGANISM(S): Pseudomonas putida 
2016-07-07 | E-GEOD-71852 | biostudies-arrayexpress
UnknownBase Excision Repair AP-Endonucleases-Like Genes Modulate DNA Damage Response and Virulence of the Human Pathogen Cryptococcus neoformans.
Not available
S-EPMC7917787 | biostudies-literature
UnknownAssessing the burden of submicroscopic Plasmodium infections in a pre-elimination malaria setting in sub-Saharan Africa, Guinea-Bissau.
Not available
S-EPMC11491027 | biostudies-literature
TranscriptomicsVibrio cholerae: Wild type El Tor biotype versus crp mutant
Transcriptional profiling of an El Tor biotype crp mutant The virulent V. cholerae El Tor Ogawa strain C7258 (Peru isolate 1991) and an isogenic deletion mutant (WL7258) lacking DNA sequences encoding the cAMP receptor protein were grown in LB medium to optical density at 600 nm of 1.5. The cultures...
ORGANISM(S): Vibrio cholerae 
2010-05-27 | E-GEOD-7519 | biostudies-arrayexpress
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