Sort   by:  
 Page size 
UnknownKL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer's disease.
Not available
S-EPMC8219708 | biostudies-literature
TranscriptomicsGlobal analysis of the RNA-protein interaction and RNA secondary structure landscapes of the Arabidopsis nucleus
Post-transcriptional regulation in eukaryotes requires cis- and trans-acting features and factors including RNA secondary structure, and RNA-binding proteins (RBPs). However, a comprehensive view of the structural and RBP interaction landscape of RNAs in the nucleus has yet to be compiled for any or...
ORGANISM(S): Arabidopsis thaliana 
2014-12-16 | E-GEOD-58974 | biostudies-arrayexpress
TranscriptomicsEvaluating the Impact of Sequencing Depth on Transcriptome Profiling in Human Adipose
Recent advances in RNA sequencing (RNA-Seq) have enabled the discovery of novel transcriptomic variations that are not possible with traditional microarray-based methods. Tissue and cell specific transcriptome changes during pathophysiological stress, in disease cases versus controls and in response...
ORGANISM(S): Homo sapiens 
2013-07-12 | E-GEOD-46323 | biostudies-arrayexpress
TranscriptomicsTranscriptome-wide ribonuclease footprinting to identify RNA-protein interaction sites
RNA-binding proteins (RBPs) are intimately involved in all aspects of RNA processing and regulation and are linked to neurodegenerative diseases and cancer. Therefore, understanding the relationship between RBPs and their RNA targets is critical for a broader understanding of post-transcriptional re...
ORGANISM(S): Homo sapiens 
2014-10-20 | E-GEOD-57881 | biostudies-arrayexpress
TranscriptomicsRNase-mediated protein footprint sequencing reveals protein-binding sites throughout the human transcriptome
RNAs are continuously associated with RNA-binding proteins (RBPs), and these interactions are necessary for many key cellular processes ranging from splicing to chromatin regulation. Although numerous approaches have been developed to map RNA-binding sites of individual RBPs, few methods exist that ...
ORGANISM(S): Homo sapiens 
2013-11-06 | E-GEOD-49309 | biostudies-arrayexpress
TranscriptomicsDetermination of RNA Secondary Structure By RNA-Sequencing of HEK293T Cells
RNA molecule fold into three dimensional structures in order to fill important roles in the cell such as translation and post-transcriptional regulation. These three dimensional structures, in turn, depend on the pattern of hydrogen bonds between ribonucleotides. We employ a technique based on high ...
ORGANISM(S): Homo sapiens 
2016-05-17 | E-GEOD-72681 | biostudies-arrayexpress
TranscriptomicsTissue-specific RNA-seq in human evoked inflammation identifies novel blood and adipose lincRNA signatures of cardio-metabolic diseases
Inappropriate or sustained activation of innate immunity is a pathologic feature of several common cardio-metabolic disorders. Little is known, however, about transcriptomic modulation during inflammatory stress in disease-relevant human tissues. We applied deep RNA sequencing (RNA-seq) during low-d...
ORGANISM(S): Homo sapiens 
2014-01-02 | E-GEOD-50792 | biostudies-arrayexpress
TranscriptomicsRegulatory and evolutionary footprints of messenger RNA secondary structure in primate transcriptomes
Messenger RNA secondary structure is critical to all aspects of post-transcriptional regulation. However, the global regulatory and evolutionary significance of mRNA secondary structure remains largely illusive. Here, we describe a transcriptome-wide analysis of RNA secondary structure in humans and...
ORGANISM(S): Homo sapiens 
2017-05-01 | E-GEOD-57295 | biostudies-arrayexpress
Transcriptomics5-azacytidine and entinostat treatment of patients with MDS, chronic myelomonocytic leukemia (CMMoL), and high risk AML
Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies. The patients with MDS, chronic myelomonocytic leukemia (CMMoL), and high risk AML were treated with sequential administration of ...
ORGANISM(S): Homo sapiens 
2009-06-20 | E-GEOD-16625 | biostudies-arrayexpress
UnknownSpillover From an Intervention on Antibiotic Prescribing for Family Physicians: A Post Hoc Secondary Analysis of a Randomized Clinical Trial.
Not available
S-EPMC12215572 | biostudies-literature
Sort   by:  
 Page size