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TranscriptomicsImproved transcription and translation with L-leucine stimulation of mTORC1
Roberts syndrome (RBS) is a human developmental disorder caused by mutations in the cohesin acetyltransferase ESCO2. We previously reported that mTORC1 was inhibited and overall translation was reduced in RBS cells. Treatment of RBS cells with L-leucine partially rescued mTOR function and protein sy...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-64962 | biostudies-arrayexpress
TranscriptomicsNext generation sequencing of Coccinella septempunctata L. with non-diapause, diapause, and diapause-terminated states
The most common ladybird beetle, Coccinella septempunctata L., is an excellent predator of crop pests such as aphids and white flies, and it shows a wide range of adaptability, a large appetite and a high reproductive ability. In this study, we collected female adults in three different states, i.e...
ORGANISM(S): Coccinella septempunctata 
2016-06-01 | E-GEOD-75645 | biostudies-arrayexpress
TranscriptomicsComparison of the transcriptional profiles of male E13.5 wild type and L/H-Pgds-/- gonads
The goals of this study are to compare transcriptome profiling of L/H-Pgds-/- gonads to that of WT (RNA-seq) Methods: mRNA profiles of E13.5 wild-type (WT) and L- and H- prostaglandin D synthases (L/H-Pgds?/?) embryonic gonad were generated by deep sequencing, in triplicate, using Illumina HiSeq20...
ORGANISM(S): Mus musculus 
2014-08-26 | E-GEOD-55744 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse expressing human Cathepsin L inhibitor hurpin, skin alterations and increased carcinogenesis.
Aim of this study was to identify gene expression differences in the skin of hurpin (=headpin=serpinB13) transgenic mice in comparison to wildtype mice. Experiment Overall Design: Comparison of 4 transgenic mice with 3 wildtype mice. One wildtye sample was used two times. Experiment Overall Design:...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5236 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of zebrafish livers following exposure to 17 alpha-ethynylestradiol (EE2) at 0, 15, 40, or 100 ng/L
Genomic, proteomic, and metabolomic technologies continue to receive increasing interest from environmental toxicologists. This interest is due to the great potential of these technologies to identify detailed modes of action and to provide assistance in the evaluation of a contaminant?s risk to aq...
ORGANISM(S): Danio rerio 
2007-02-24 | E-TABM-105 | biostudies-arrayexpress
TranscriptomicsAnalysis of human myeloma cell lines expressing beta 3 integrin
The aim of these experiments was designed to compare gene expression in human myeloma cell lines expressing beta 3 integrin vs counterpart cell lines that do not express beta 3 integrin. Keywords: Gene expression,cell lines, siRNA Phenotype characterization of both primary and cultured myeloma plas...
ORGANISM(S): Homo sapiens 
2010-05-19 | E-GEOD-15867 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophages infected with Leishmania major or Leishmania donovani
Murine bone marrow derived macrophages were infected with Leishmania major or Leishmania donovania promastigotes, allowed to phagocytose latex beads or not treated. Gene expression profiles were compared to identify i) the effect of Leishmania infection; ii) the differences in effects between L. maj...
ORGANISM(S): Mus musculus 
2008-02-05 | E-MEXP-1254 | biostudies-arrayexpress
UnknownFirst Description of Sarcoptic Mange in a Free-Ranging European Wildcat (Felis silvestris silvestris) from Spain.
Not available
S-EPMC8466406 | biostudies-literature
TranscriptomicsTranscription profiling of male and female sticklebacks exposed to dibenzathracene, oestradiol or a combination of the two for 48 hours
Male and five female sticklebacks were exposed to the single compounds dibenzanthracene (DbA, Sigma Aldrich, Cat No D-31400) (40ug/L DbA in 0.0125% acetone) and oestradiol (E2, Sigma, Cat No E-8875) (50 ng/L E2 in 0.0125% acetone) or binary DbA + E2 (40ug/L DbA + 50ng/L E2 in 0.0125% acetone) in add...
ORGANISM(S): Gasterosteus aculeatus 
2008-02-08 | E-MAXD-39 | biostudies-arrayexpress
GenomicsWhole genome sequencing of spontaneous resistant mutants of Mycobacterium tuberculosis H37Rv selectec in the presence of BVL3572S and amino acids
M. tuberculosis H37Rv cultures were exposed to BVL3572S in the absence or presence of L-histidine or L-alanine for at least 4 weeks. Individual colonies were picked and their genomic DNA extracted, indexed, and sequenced.
ORGANISM(S): Mycobacterium tuberculosis 
2026-06-03 | E-MTAB-17255 | biostudies-arrayexpress
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