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MetabolomicsHif1α-Dependent Uncoupling Of Glycolysis Suppresses Tumor Cell Proliferation
Hypoxia-inducible factor-1α (HIF1α) attenuates mitochondrial activity while promoting glycolysis. Paradoxically, it remains unknown why lower glycolysis is compromised in human clear cell renal cell carcinomas (ccRCC), in which HIF1α acts a tumor suppressor by inhibiting cell autonomous proliferatio...
2024-03-15 | MTBLS8901 | MetaboLights
UnknownRandomized Phase III Study of FOLFOX Alone or With Pegilodecakin as Second-Line Therapy in Patients With Metastatic Pancreatic Cancer That Progressed After Gemcitabine (SEQUOIA).
Not available
S-EPMC8078437 | biostudies-literature
Genomics7a35ed9c-c0d2-4f56-92d4-732940fc4b0a - samples
WGS data of plasma samples from healthy individuals (N=29)
EGAD00001006421 | EGA
Genomicsd8d22c07-127f-41fe-804e-e9508a9d358d - samples
WGS data of plasma samples from BRCA patients (N=10)
EGAD00001006420 | EGA
Genomics6b067da7-9de4-4f80-b496-ee90666ceda1 - samples
WGS data of plasma samples from CRC patients (N=12)
EGAD00001006419 | EGA
Genomics32f542a0-6702-47f2-b7d3-25b0c268fe31 - samples
WGS data of buffy coat from CRC patients
EGAD00001008352 | EGA
GenomicsTissue-specific cell-free DNA degradation quantifies circulating tumor DNA burden
Profiling of circulating tumor DNA (ctDNA) may offer a non-invasive approach to monitor disease progression. Here, we developed a quantitative method, exploiting local tissue-specific cell-free DNA (cfDNA) degradation patterns, that accurately estimates ctDNA burden independent of genomic aberration...
EGAS00001004657 | EGA
GenomicsPlasma DNA - GIS
Data Access Committee EGAC00001001733
EGAC00001001733 | EGA
UnknownEnhanced postoperative surveillance versus standard of care to reduce mortality among adult surgical patients in Africa (ASOS-2): a cluster-randomised controlled trial.
Not available
S-EPMC8440223 | biostudies-literature
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