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ProteomicsQuantitative proteomics on wt-MCF7 versus their LTED derivatives using dimethyl labelling
Wild type (wt) MCF7 cells, modelling breast cancer at primary diagnosis, were cultured in phenol red-free RPMI supplemented with 10% FBS and 1nM estradiol (E2). Long-term oestrogen deprived (LTED) cell lines, which model resistance to endocrine therapy, were cultured in phenol red-free RPMI in the a...
ORGANISM(S): Homo sapiens (Human) 
2016-06-01 | PXD004085 | Pride
Mcf7 Lted Dimethyl labelling 
ProteomicsResistance to Palbociclib requires multiple targetable mechanisms highlighting the potential of drug holidays and drug switching to improve therapeutic outcome
Estrogen receptor positive (ER+) breast cancer is the most common type of breast cancer. Despite the great efficacy of endocrine therapies, resistance remains a problem. Therefore, there is an immediate need for new, effective therapies in ER+ BC. In this study, we have explored the role of a potent...
ORGANISM(S): Homo sapiens (Human) 
2020-03-25 | PXD005611 | Pride
Breast cancer Proteomics Resistance Palbociclib 
ProteomicsComparative shotgun proteomics in wt-SUM44 and SUM44-LTED, using RIME and dimethyl-labelling
Wild type (wt) SUM44 cells, modelling breast cancer at primary diagnosis, were cultured in phenol red-free RPMI supplemented with 10% FBS and 1nM estradiol (E2). Long-term oestrogen deprived (LTED) cell lines, which model resistance to endocrine therapy, were cultured in phenol red-free RPMI in the ...
ORGANISM(S): Homo sapiens (Human) 
2017-12-11 | PXD004807 | Pride
Breast cancer Rime Dimethyl-labelling Sum44 
ProteomicsElacestrant demonstrates strong anti-estrogenic activity in PDX models of estrogen receptor positive endocrine-resistant and fulvestrant-resistant breast cancer
Human breast cancer cell lines were cultured in phenol red-free RPMI1640 medium supplemented with 10% fetal bovine serum and 1nM E2. All cell lines were banked in multiple aliquots to reduce the risk of phenotypic drift and identity confirmed using STR. Cells were routinely screened for mycoplasma c...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD031377 | Pride
Tmt Elacestrant Rime Breast cancer 
ProteomicsER-RIME in wt-MCF7 and MCF7-LTED
Wild type (wt) MCF7 cells, modelling breast cancer at primary diagnosis, were cultured in phenol red-free RPMI supplemented with 10% FBS and 1nM estradiol (E2). Long-term oestrogen deprived (LTED) cell lines, which model resistance to endocrine therapy, were cultured in phenol red-free RPMI in the a...
ORGANISM(S): Homo sapiens (Human) 
2020-07-13 | PXD004648 | Pride
Breast cancer Mcf7 Rime Lc-ms/ms 
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