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ProteomicsComparative shotgun proteomics in wt-SUM44 and SUM44-LTED, using RIME and dimethyl-labelling
Wild type (wt) SUM44 cells, modelling breast cancer at primary diagnosis, were cultured in phenol red-free RPMI supplemented with 10% FBS and 1nM estradiol (E2). Long-term oestrogen deprived (LTED) cell lines, which model resistance to endocrine therapy, were cultured in phenol red-free RPMI in the ...
ORGANISM(S): Homo sapiens (Human) 
2017-12-11 | PXD004807 | Pride
Breast cancer Rime Dimethyl-labelling Sum44 
TranscriptomicsTranscription profiling of human SUM44 and LCCTam cells reveals ERRgamma mediates Tamoxifen resistance in novel models of invasive lobular breast cancer
One-third of all ER+ breast tumors treated with endocrine therapy fail to respond, and the remainder are likely to relapse in the future. Almost all data on endocrine resistance has been obtained in models of invasive ductal carcinoma (IDC). However, invasive lobular carcinomas (ILC) comprise up to...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-12708 | biostudies-arrayexpress
GenomicsRNA-Seq analysis of long-term estrogen-deprived (LTED) MDA-MB-134VI (MM134) and SUM44PE (SUM44) ILC cell lines
RNA-Seq analysis of long-term estrogen-deprived (LTED) MDA-MB-134VI (MM134) and SUM44PE (SUM44) ILC cell lines
PRJNA480032 | ENA
TranscriptomicsAmplification of WHSC1L1 regulates expression and estrogen independent activation of ERα in SUM 44 cells and is associated with ERα over-expression in breast cancer
Estrogen receptor positive breast cancer is the most prevalent form of breast cancer. Although a number of available drugs are highly effective at blocking estrogen mediated receptor activity, thousands of patients die every year from ER positive breast cancers because the disease progresses to a st...
ORGANISM(S): Homo sapiens 
2016-05-07 | E-MTAB-3739 | biostudies-arrayexpress
TranscriptomicsRNA-Seq analysis of long-term estrogen-deprived (LTED) MDA-MB-134VI (MM134) and SUM44PE (SUM44) ILC cell lines
Background: Invasive lobular breast carcinoma (ILC) is a histological subtype of breast cancer that is characterized by loss of E-cadherin, and high expression of estrogen receptor alpha (ER). Many patients with ILC are effectively treated with adjuvant aromatase inhibitors (AIs), however, acquired ...
ORGANISM(S): Homo sapiens 
2018-08-30 | GSE116744 | GEO
GenomicsGlucocorticoid Receptor Activation in Lobular Breast Cancer is Associated with Reduced Cell Proliferation and Promotion of Metastases SUM44-GR-GFP
Glucocorticoid Receptor Activation in Lobular Breast Cancer is Associated with Reduced Cell Proliferation and Promotion of Metastases SUM44-GR-GFP
PRJNA1010890 | ENA
TranscriptomicsERRγ mediates Tamoxifen resistance in novel models of invasive lobular breast cancer
One-third of all ER+ breast tumors treated with endocrine therapy fail to respond, and the remainder are likely to relapse in the future. Almost all data on endocrine resistance has been obtained in models of invasive ductal carcinoma (IDC). However, invasive lobular carcinomas (ILC) comprise up to ...
ORGANISM(S): Homo sapiens 
2008-11-01 | GSE12708 | GEO
GenomicsUnbiased Capture Hi-C reveals the potential targets of breast cancer susceptibility loci
Genome-wide association studies have identified over 70 common variants that are associated with breast cancer risk. Most of these variants map to non-protein-coding regions; several map to gene deserts, regions of several hundred kb lacking protein-coding genes. We hypothesized that gene deserts ha...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-55634 | biostudies-arrayexpress
GenomicsCapture Hi-C profiling of SUM44 breast cancer cell line
This study investigates different read depths of biological replicates for reproducibility and benchmarking of Capture Hi-C assays.
PRJEB30128 | ENA
UnknownTranscription profiling of human SUM44 and LCCTam cells reveals ERRgamma mediates Tamoxifen resistance in novel models of invasive lobular breast cancer
Not available
ORGANISM(S): Homo sapiens 
S-ECPF-GEOD-12708 | biostudies-other
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