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TranscriptomicsCGH profiles of primary breast carcinomas from HBOC (Hereditary Breast and Ovarian Cancer) families
89 tumors from women that were eligible for, and subjected to, routine diagnostic testing according to the HBOC criteria but were negative for pathogenic BRCA1/2-mutations or carried an UV in either BRCA1/2 A BRCA2-classifier was built using array-CGH profiles of 28 BRCA2-mutated and 28 sporadic bre...
ORGANISM(S): Homo sapiens 
2010-07-05 | E-GEOD-22481 | biostudies-arrayexpress
TranscriptomicsExpression data in splenic DC subsets in wild type and Xbp1 deficient mice
Xbp1 is a major transcription factor in the unfolded protein response. To uncover its function in DCs we generated a conditional KO for Xbp1 in dendritic cells. We here compare the expression of mRNAs in two different splenic DC subpopulations, CD8a and CD11b DCs in both WT and KO mice. Reference: I...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-52857 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of mouse Brca1 and Brca2 mammary tumors
Comparison of mammary tumors from 35 Brca1F/F;p53F/F, 62 Brca2F/F;p53F/F and 33 p53F/F mice. For each mouse, tumor DNA was hybridized with its spleen DNA as a reference.
ORGANISM(S): Mus musculus 
2010-12-15 | E-NCMF-34 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of mouse Brca1 and Brca2 mammary tumors
Comparison of mammary tumors from 35 Brca1F/F;p53F/F, 62 Brca2F/F;p53F/F and 33 p53F/F mice. For each mouse, tumor DNA was hybridized with its spleen DNA as a reference.
ORGANISM(S): Mus musculus 
2010-12-15 | E-NCMF-35 | biostudies-arrayexpress
Genomics58BC - samples
WTCCC2 samples from 1958 British Birth Cohort
EGAD00010000234 | EGA
GenomicsT2D - samples
WTCCC2 samples from Type 2 Diabetes Cohort
EGAD00010000232 | EGA
GenomicsHT - samples
WTCCC2 samples from Hypertension Cohort
EGAD00010000230 | EGA
GenomicsCAD - samples
WTCCC2 samples from Coronary Artery Disease Cohort
EGAD00010000236 | EGA
GenomicsAssociation studies using the Metabochip array - Samples analysed by the WTCCC (1958 British Birth Cohort (58BC), Hypertension cohort (HT), Type 2 Diabetes Cohort (T2D) and Coronary Artery Disease (CAD) cohort)
Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effectiv...
EGAS00000000115 | EGA
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