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UnknownIntentional interruptions during compression only CPR: A scoping review.
Not available
S-EPMC11000192 | biostudies-literature
UnknownIntermittent fasting enhances cisplatin-metformin efficacy in therapy-resistant ovarian cancer PDXs.
Not available
S-EPMC12803865 | biostudies-literature
UnknownEligibility criteria for clinical trials in AL amyloidosis result in exclusion of nearly half of real-world patients.
Not available
S-EPMC12908192 | biostudies-literature
UnknownCharacterization of the "gut microbiota-immunity axis" and microbial lipid metabolites in atrophic and potential celiac disease.
Not available
S-EPMC9561818 | biostudies-literature
ProteomicsBiofabrication of a 3D Human Skeletal Muscle Microenvironment to Study the Early Steps of Fibrosis
Skeletal muscle fibrosis is a prevalent characteristic of aging and dystrophies. Beyond myofibroblast involvement, recent findings highlighted a complex cellular cross-talk within the muscle microenvironment, finally resulting in vascular and tissue damage. This complexity is not captured by current...
ORGANISM(S): Homo sapiens (Human) 
2025-10-31 | PXD061757 | Pride
Biofabrication Endothelial-mesenchymal transition Microphysiological system Skeletal muscle Microvascular network 
ProteomicsDevelopment of a proteomic workflow for the identification of heparan sulfate proteoglycan-binding substrates of ADAM17. Evaluation of heparin effects on sample preparation by FASP.
Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell-to-cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and grow...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-23 | PXD054987 | Pride
Sheddome Adam17 Ectodomain shedding Disintegrin metalloproteinases Secretome 
ProteomicsiRhom2 regulates HMGB1 secretion to modulate inflammation and hepatocyte senescence in an in vitro model of ischemia/reperfusion injury
Background and Aims: Ischemia/reperfusion injury (IRI), considered one of the most important causes of liver organ rejection in acute and chronic phases, generates an inflammatory environment leading to compromised allograft functionality and rejection. In the last ten years, iRhom2 emerged as an es...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD046469 | Pride
Liver transplant  ischemia/reperfusion  inflammation  irhom2  hmgb1  cellular senescence  secretomics. 
TranscriptomicsBisulfite-Seq and RNA-seq profiling of truffle (Tuber melanosporum)
We investigated the ascomycete truffle Tuber melanosporum exploits DNA methylation and transcription to cope with the more than 45,000 repeated elements that are present in its genome. Whole-genome bisulfite sequencing and RNA-sequencing, were performed on different developmental stages of this symb...
ORGANISM(S): Tuber melanosporum 
2014-01-01 | E-GEOD-49700 | biostudies-arrayexpress
ProteomicsDevelopment of a proteomic workflow for the identification of heparan sulfate proteoglycan-binding substrates of ADAM17 - Evaluation of heparin effects on sample preparation PreOmics
Ectodomain shedding, which is the proteolytic release of transmembrane proteins from the cell surface, is crucial for cell-to-cell communication and other biological processes. The metalloproteinase ADAM17 mediates ectodomain shedding of over 50 transmembrane proteins ranging from cytokines and grow...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD055002 | Pride
Sheddome Adam17 Ectodomain shedding Heparin Disintegrin metalloproteinases Secretome 
ProteomicsProteomic analysis and functional validation reveal distinct therapeutic capabilities related to priming of mesenchymal stromal/stem cells with IFN-γ and hypoxia: potential implications for their clinical use
Mesenchymal stromal/stem cells (MSCs) are a heterogeneous population of multipotent cells that can be obtained from various tissues, such as dental pulp, adipose tissue, bone marrow and placenta. MSCs have gained importance in the field of regenerative medicine because of their promising role in cel...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD052445 | Pride
Msc priming Msc therapeutic properties Proteomic analysis Msc paracrine effects Placenta-derived mesenchymal stromal/stem cells Ifn-γ priming Hypoxia priming 
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