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ProteomicsMolecular identification of a BAR domain-containing coat complex for endosomal recycling of transmembrane proteins
Protein trafficking requires coat complexes that couple recognition of sorting motifs in transmembrane cargos with biogenesis of transport carriers. The mechanisms of cargo transport through the endosomal network are poorly understood. Here, we identify a sorting motif for endosomal recycling of car...
ORGANISM(S): Homo sapiens (Human) 
2021-05-28 | PXD014927 | Pride
Snx-bars Endosomes Transmembrane proteins Endocytosis Ci-mpr 
ProteomicsSorting nexin-27 regulates AMPA receptor trafficking through the synaptic adhesion protein LRFN2
The endosome-associated cargo adaptor sorting nexin-27 (SNX27) is linked to various neuropathologies through sorting of integral proteins to the synaptic surface, most notably AMPA receptors. To provide a broader view of SNX27-associated pathologies we performed proteomics in rat primary neurons to ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-06-28 | PXD026289 | Pride
Membrane trafficking Snx27 Lrfn2 Ampa receptors 
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