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TranscriptomicsEffect of simvastatin on pancreatic cancer cells
The aim of our study was to assess the impact of simvastatin on the amount of cytosolic lipid droplets (LDs), which are implicated in many biological processes including proliferation, inflammation, carcinogenesis, apoptosis, necrosis or growth arrest. Human pancreatic cancer cells MiaPaCa-2 were t...
ORGANISM(S): Homo sapiens 
2013-11-21 | E-MTAB-1501 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood monocytes treated with simvastatin reveals it has an anti-inflammatory effect on macrophages via upregulation of Kruppel-like factor-2
HMG-CoA reductase inhibitors, statins, have beneficial vascular effects beyond their cholesterol-lowering action. These pleiotropic effects include an anti-inflammatory effect on macrophages. Since macrophages play a central role in atherogenesis, we further characterized the effects on peripheral b...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4883 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse lung samples treated with Simvastatin and LPS and corresponded controls
This series contain mouse lung samples treated with Simvastatin and LPS and corresponded controls.
ORGANISM(S): Mus musculus 
2007-11-09 | E-GEOD-1871 | biostudies-arrayexpress
TranscriptomicsSimvastatin treated Lymphoblastoid Cell lines from Cholesterol and Pharmacogenomics (CAP) Trial
Statins reduce cardiovascular disease risk by lowering plasma low density lipoprotein (LDL)-cholesterol. To identify novel pathways that modulate statin response, we assessed the influence of simvastatin exposure on expression quantitative trait locus (eQTL) associations across the genome in 480 ly...
ORGANISM(S): Homo sapiens 
2012-06-30 | E-GEOD-36868 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse model oradiation induced lung injury reveals Simvastatin attenuates lung vascular leak and inflammation
Background: Microvascular injury and increased vascular leakage are prominent features of the radiation-induced lung injury (RILI) which follows cancerâ??associated thoracic irradiation. The mechanisms of RILI are incompletely understood and therapeutic strategies to limit RILI are currently unavail...
ORGANISM(S): Mus musculus 
2009-03-07 | E-GEOD-14431 | biostudies-arrayexpress
GenomicsSimvastatin modulates osteogenic differentiation in stem cells isolated from apical papilla
Simvastatin modulates osteogenic differentiation in stem cells isolated from apical papilla
PRJNA1209887 | ENA
GenomicsTranscriptomic profiling of simvastatin-treated human umbilical vein endothelial cells
Transcriptomic profiling of simvastatin-treated human umbilical vein endothelial cells
PRJNA718475 | ENA
GenomicsGene expression profiling of human neuroblastoma cell line SMS-KCNR treated with DMSO, simvastatin at 5 µM or simvastatin at 5 µM plus mevalonate at 2 mM for 30 hours
Gene expression profiling of human neuroblastoma cell line SMS-KCNR treated with DMSO, simvastatin at 5 µM or simvastatin at 5 µM plus mevalonate at 2 mM for 30 hours
PRJNA891335 | ENA
ClinicalTrial of XELIRI/FOLFIRI + Simvastatin Followed by Simvastatin Maintenance in Metastatic Colorectal Cancer
The purpose of this study is to compare 2nd line XELIRI/FOLFIRI + simvastatin vs XELIRI/FOLFIRI + placebo.
2097860 | ecrin-mdr-crc
UnknownSimvastatin as a treatment for pulmonary hypertension trial.
Not available
S-EPMC2874452 | biostudies-literature
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