Sort   by:  
 Page size 
TranscriptomicsInducible repositioning of mouse gene tethering to the inner nuclear membrane
Nuclear compartmentalization appears to play an important role in regulating metazoan genes. While studies on immunoglobulin (Ig) and other loci have correlated positioning at the nuclear lamina with gene repression, the functional consequences of this compartmentalization remain untested. We devise...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10176 | biostudies-arrayexpress
TranscriptomicsRegulation of bifurcating B cell trajectories by mutual antagonism between IRF4 and IRF8 (RNA-Seq)
Upon antigen recognition B cells undertake a bifurcated response in which some cells rapidly differentiate into plasmablasts while others undergo affinity maturation in germinal centers (GC). We uncover a double negative feedback loop between interferon regulatory factors IRF4 and IRF8, which regula...
ORGANISM(S): Mus musculus 
2015-08-25 | E-GEOD-70711 | biostudies-arrayexpress
GenomicsRegulation of bifurcating B cell trajectories by mutual antagonism between IRF4 and IRF8
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-08-25 | E-GEOD-70712 | biostudies-arrayexpress
GenomicsRegulation of bifurcating B cell trajectories by mutual antagonism between IRF4 and IRF8 (ChIP-Seq)
Upon antigen recognition B cells undertake a bifurcated response in which some cells rapidly differentiate into plasmablasts while others undergo affinity maturation in germinal centers (GC). We uncover a double negative feedback loop between interferon regulatory factors IRF4 and IRF8, which regula...
ORGANISM(S): Mus musculus 
2015-08-25 | E-GEOD-70710 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse IRF4,8 null pre-B cells treated with ILF7 reveals convergent molecular pathways that induce immunoglobulin light-chain recombination
Productive rearrangement of the immunoglobulin heavy chain locus triggers a major developmental checkpoint that promotes limited clonal expansion of pre-B cells, culminating in cell cycle arrest and rearrangement of the kappa (κ) or lambda (λ) light-chain loci. B lineage cells lacking the related...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10273 | biostudies-arrayexpress
TranscriptomicsSimple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
Genome-scale studies have revealed extensive co-localization of transcription factors in a given cell type as well as substantial differences in the binding patterns of specific transcription factors between cell types. Several mechanisms have been proposed to explain these observations, including t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21512 | biostudies-arrayexpress
UnknownPEPstrMOD: structure prediction of peptides containing natural, non-natural and modified residues.
Not available
S-EPMC4687368 | biostudies-literature
UnknownThe independent prognostic value of global epigenetic alterations: An analysis of single-cell ATAC-seq of circulating leukocytes from trauma patients followed by validation in whole blood leukocyte transcriptomes across three etiologies of critical illness.
Not available
S-EPMC8822299 | biostudies-literature
GenomicsTranscriptional regulation of germinal center B and plasma cell fates by dynamical control of IRF4 (ChIP-seq)
Temporal analysis of Irf4 and PU.1 genome binding during B cell activation and differentiation in vitro using antigen (NP-Ficoll) CD40L and IL-2/4/5 cytokines (see Molecular Systems Biology 7:495 for details of cellular system). The results provide insight in the target genes and binding specificity...
ORGANISM(S): Mus musculus 
2013-05-04 | E-GEOD-46607 | biostudies-arrayexpress
ProteomicsPredictive Signatures of 19 Antibiotic-Induced Escherichia coli Proteomes
Identifying the mode of action (MOA) of antibacterial compounds is the fundamental basis for the development of new antibiotics, and the challenge increases with the emerging secondary and indirect effect from antibiotic stress. Although various omics-based system biology approaches are currently av...
ORGANISM(S): Escherichia Coli K-12 (ncbitaxon:83333) 
2020-10-09 | MSV000086253 | MassIVE
Sort   by:  
 Page size