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TranscriptomicsTachyzoite to bradyzoite differentiation
Developmental switching in Toxoplasma gondii, from the virulent tachyzoite to the relatively quiescent bradyzoite stage, is responsible for disease propagation and reactivation. We have generated tachyzoite to bradyzoite differentiation (Tbd-) mutants in T. gondii and used these in combination with ...
ORGANISM(S): Toxoplasma gondii 
2005-08-13 | E-GEOD-3117 | biostudies-arrayexpress
TranscriptomicsDifferentiation mutants in the protozoan parasite Toxoplasma gondii.
Two forms of the protozoan parasite Toxoplasma gondii are associated with intermediate hosts such as humans: rapidly growing tachyzoites are responsible for acute illness, whereas slowly dividing encysted bradyzoites can remain latent within the tissues for the life of the host. In order to identify...
ORGANISM(S): Toxoplasma gondii 
2005-08-13 | E-GEOD-3119 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Toxoplasma gondii tachyzoite to bradyzoite differentiation mutants
Developmental switching in Toxoplasma gondii, from the virulent tachyzoite to the relatively quiescent bradyzoite stage, is responsible for disease propagation and reactivation. We have generated tachyzoite to bradyzoite differentiation (Tbd-) mutants in T. gondii and used these in combination with ...
ORGANISM(S): Toxoplasma gondii 
2005-07-21 | E-SMDB-1404 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Toxoplasma gondii tachyzoite to bradyzoite differentiation mutants
Two forms of the protozoan parasite Toxoplasma gondii are associated with intermediate hosts such as humans: rapidly growing tachyzoites are responsible for acute illness, whereas slowly dividing encysted bradyzoites can remain latent within the tissues for the life of the host. In order to identify...
ORGANISM(S): Toxoplasma gondii 
2005-07-21 | E-SMDB-1406 | biostudies-arrayexpress
TranscriptomicsEffects of overexpression of EhMyb-dr on transcription in Entamoeba histolytica
A myb domain containing protein of the SHAQKY family, EhMyb-dr, was overexpressed in E. histolytica trophozoites, and effects on transcription were measured. Two arrays of trophozoites expressing Myc tagged EhMyb-dr were compared to two arrays performed on wild type trophozoites. The effects of tran...
ORGANISM(S): Entamoeba histolytica 
2009-03-01 | E-GEOD-13023 | biostudies-arrayexpress
TranscriptomicsComparison of normal and heat shock trophozoites
We examined the stress response in Entamoeba histolytica trophozoites by comparing untreated log-phase HM-1:IMSS trophozoites to those subjected to heat shock at 42C for 1 hour. Keywords: stress reponse We compared two arrays from normal trophozoites to two arrays from trophozoites subjected to heat...
ORGANISM(S): Entamoeba histolytica 
2007-03-01 | E-GEOD-6650 | biostudies-arrayexpress
TranscriptomicsSmall RNA pyrosequencing in the protozoan parasite Entamoeba histolytica reveals strain-specific small RNAs that target virulence genes
We provided a full spectrum analysis for E. histolytica AGO2-2 associated 27nt small RNAs. Additionally, comparative analysis of small RNA populations from virulent and non-virulent amebic strains indicates that small RNA populations may regulate virulence genes. AGO2-2 bound small RNAs from E. hist...
ORGANISM(S): Entamoeba histolytica 
2013-01-24 | E-GEOD-43668 | biostudies-arrayexpress
TranscriptomicsExpression data of E. histolytica trophozoites treated with 5AzaC
Expression profiling of treatment of E. histolytica HM-1:IMSS trophozoites with 5-Aza cytidine, an inhibitor of DNA methyltransferase Keywords: drug treatment HM1 trophozoites were treated for 3 or 7 days with 23 micromolar 5-Aza cytidine, and RNA extracted and analyzed on a custom Affymetrix array...
ORGANISM(S): Entamoeba histolytica 
2007-03-01 | E-GEOD-6635 | biostudies-arrayexpress
TranscriptomicsEffect of treatment with H2O2 or DPTA-NONOate on E. histolytica
E. histolytica of strains HM1:IMSS (virulent) and Rahman (avirulent) were examined for response to oxidative and nitrosative stress. Response to oxidative stress in E. histolytica was assayed by treating Eh (HM1:IMSS) and Eh (Rahman) with 1mM H2O2 for 60 minutes or 90 minutes and comparing transcri...
ORGANISM(S): Entamoeba histolytica 
2008-09-30 | E-GEOD-11811 | biostudies-arrayexpress
TranscriptomicsGene expression in Entamoeba histolytica cysts and trophozoites
We compared multiple strains of lab trophozoites to recent clinical isolates. Clinical isolates were grown in xenic media, and maintained many characteristics of the cyst stage of devlopment Keywords: Stage conversion E. histolytica trophozoites of three different strains (HM1:IMSS, Rahman, and 200:...
ORGANISM(S): Entamoeba histolytica 
2007-03-01 | E-GEOD-6648 | biostudies-arrayexpress
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