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ProteomicsHigh-throughput Proteomics fiber typing (ProFiT) for comprehensive characterization of single skeletal muscle fibers
Skeletal muscles are composed of a heterogeneous collection of fiber types with different physiological adaption in response to a stimulus and disease-related conditions. Each fiber has a specific molecular expression of myosin heavy chain molecules (MyHC). So far MyHCs are currently the best marker...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-02 | PXD017755 | Pride
Muscle fiber proteomics Protein turnover Phosphoproteomics Myhc profiling 
ProteomicsSingle muscle fiber proteomics reveals fiber type-specific features of human muscle aging
Skeletal muscle is a key tissue in human aging, which affects different muscle fiber types unequally. We developed a highly sensitive single muscle fiber proteomics workflow to study human aging and show that the senescence of slow and fast muscle fibers is characterized by diverging metabolic and p...
ORGANISM(S): Homo sapiens (Human) 
2017-06-14 | PXD006182 | Pride
Muscle fibers Skeletal muscle Aging 
ProteomicsSingle muscle fiber proteomics reveals unexpected mitochondrial specialization
Mammalian skeletal muscles are composed of multinucleated cells termed slow or fast fibers according to their contractile and metabolic properties. Here we developed a high sensitivity workflow to characterize the proteome of single fibers. Analysis of segments of the same fiber by traditional and u...
ORGANISM(S): Mus musculus (Mouse) 
2015-02-05 | PXD001641 | Pride
Metabolism Muscle fibers Single cell Exercise Mitochondria 
ProteomicsSingle muscle fiber proteomics reveals remodeling of focal adhesions in response to muscle unloading and microgravity
Spaceflight causes loss of muscle mass and strength, metabolic remodeling and insulin resistance, contributing to severe challenges for astronaut health. We used highly sensitive proteomics to detail single fiber type-specific molecular remodeling caused by muscle unloading in subjects undergoing pr...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD028435 | Pride
Proteomics Microgravity Muscle 
ProteomicsIntegrated Single-Fiber Multi-Omics in ICU-acquired weakness
Skeletal muscle dysfunction is a pervasive complication of critical illness that worsens survival and recovery, yet remains poorly explained by current clinical or molecular markers. To directly connect disease-associated molecular states to the contractile machinery, this study combined sequential ...
ORGANISM(S): Homo sapiens (Human) 
2026-10-20 | PXD073993 | Pride
Critical illness Myosin energetics Multi-omics Muscle weakness Skeletal muscle heterogeneity Single-fiber analysis 
TranscriptomicsThe evolution of spinable cotton fiber entailed prolonged development and a novel metabolism
exceptional example of evolutionary innovation is the single-celled seed trichome in Gossypium ("cotton fiber"). We have used fiber development in Gossypium as a system to understand how morphology can rapidly evolve. Fiber has undergone considerable morphological changes between the short, tightly...
ORGANISM(S): Gossypium herbaceum 
2010-06-25 | E-GEOD-10228 | biostudies-arrayexpress
GenomicsIntegrated single-cell multiome analysis resolves muscle fiber-type gene regulatory circuitry modulated by endurance exercise
Integrated single-cell multiome analysis resolves muscle fiber-type gene regulatory circuitry modulated by endurance exercise
PRJNA1002144 | ENA
ProteomicsEnlightening the decay: a combined experimental and computational analysis of mantATP turnover in skinned muscle fibers
Myosin is the primary motor protein in skeletal muscle, responsible for ATP hydrolysis that drives muscle contraction. In addition to force production, myosin consumes ATP during rest in futile cycles, a phenomenon associated with the Super Relaxed State (SRX), distinct from the disordered Relaxed S...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2025-04-30 | PXD060451 | Pride
Myh extraction Ghost fiber Single cell Muscle 
MetabolomicsAn integrated drug repositioning analysis for sarcopenia

Global population aging with increased longevity has incurred a higher prevalence of sarcopenia. Sarcopenia is characterized by age-related muscle/strength loss and is becoming a highly important public health issue. The development of sarcopenia increases the risk of various adverse health outco...

2026-01-09 | MTBLS9582 | MetaboLights
MetabolomicsLipidomic analysis of lipid droplets from murine hepatocytes reveals distinct signatures for nutritional stress
Liver steatosis can be induced by fasting or high-fat diet. We investigated by lipidomic analysis whether such metabolic states are reflected in the lipidome of hepatocyte lipid droplets (LDs) from mice fed normal chow diet (FED), fasted (FAS), or fed a high-fat diet (HFD). LC-MS/MS at levels of lip...
2014-08-19 | MTBLS26 | MetaboLights
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