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ProteomicsProteomic Analysis of the Effects of Simulated Microgravity in GES-1 Cells
Microgravity is an ecological factor that affect the environment of the body. In this study, quantitative isobaric labeling (tandem mass tag) methods were used to study the changes in human gastric mucosal cells under simulated microgravity.
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD026675 | Pride
Ges-1 cells lc-ms/ms simulated microgravity 
TranscriptomicsGlobal gene expression profiles of cardiac progenitors differentiated from human pluripotent stem cells in 3D culture under simulated microgravity
Methods: RNA-seq libraries were prepared using the Illumina TruSeq RNA kit and the TrueSeq method was employed for mRNA enrichment. The libraries were quantified and samples were multiplexed in each lane of the flowcell. Cluster generation was performed and then sequenced on the Illumina HiSeq1000 s...
ORGANISM(S): Homo sapiens 
2016-08-08 | E-GEOD-84582 | biostudies-arrayexpress
UnknownMagnetic phase separation in microgravity.
Not available
S-EPMC9359988 | biostudies-literature
TranscriptomicsTranscription profiling of S. cerevisiae cultures grown under low shear-modeled microgravity
The goal of this study was to assess whether low shear-modeled microgravity (LSMMG) effects yeast ,genomic expression patterns using the powerful tool of whole genome microarray hybridization. We determined ,changes in the yeast model organism, Saccharomyces cerevisisae, when grown in LSMMG using th...
ORGANISM(S): Saccharomyces cerevisiae 
2007-07-07 | E-GEOD-4136 | biostudies-arrayexpress
ProteomicsThe secretome of cultured human endothelial cells in modelled microgravity
Using chromatography-mass spectrometry on an Ultimate 3000 chromatograph combined with a Maxis 4G mass spectrometer, the secretome of human umbilical vein endothelial cells (HUVEC) cultured under static conditions and modeling microgravity for 24 hours was studied. In the secretome of cells under mi...
ORGANISM(S): Homo sapiens (Human) 
2026-07-01 | PXD013497 | Pride
Endothelial cells Microtubules Rho-gtpases Secretome Chromatography-mass spectrometry 
Transcriptomicsaction of microgravity on root development-Action of microgravity on root development
au11-03_gravite - action of microgravity on root development - Action of microgravity on root development - Arabidopsis were grown on horizontal or vertical clinostat for 4, 8 or 12 days. Seedlings on horizontal clinostat were in simulated microgravity and seedlings on vertical clinostat are conside...
ORGANISM(S): Arabidopsis thaliana 
2012-07-31 | E-GEOD-39631 | biostudies-arrayexpress
ProteomicsProteomics of intestine in simulated microgravity rats
After 14 days simulated microgravity，rats jejunal mucosa was taken for proteomic study. A total of 1826 proteins were detected, and 335 differentially expressed proteins were detected, of which 190 were up-regulated and 145 were down-regulated.
ORGANISM(S): Rattus Norvegicus 
2020-09-17 | PXD021522 |
Proteomics1 Enhanced assembly of bacteriophage T7 produced in cell-free reactions under simulated microgravity
On-demand biomanufacturing has the potential to improve healthcare and self- sufficiency during space missions. Cell-free transcription and translation reactions combined with DNA blueprints can produce promising therapeutics like bacteriophages and virus-like particles. However, how space condition...
ORGANISM(S): Escherichia coli 
2024-03-13 | PXD044176 | Pride
T7 phage Proteomics Microgravity 
TranscriptomicsThe Role of PTHrP in Osteoblast Response to Microgravity: Implications for Osteoporosis Development.
Prolonged skeletal unloading through bedrest results in bone loss similar to that observed in elderly osteoporotic patients, but with an accelerated timeframe. This rapid effect on weight-bearing bones is also observed in astronauts who lose up to 2% of their bone mass per month spent in Space. Des...
ORGANISM(S): Mus musculus 
2016-08-09 | E-GEOD-78980 | biostudies-arrayexpress
ProteomicsSimulated microgravity-induced changes in SUMOylation and protein expression in Saccharomyces cerevisiae
This study investigated the impact of simulated microgravity (SMG) on SUMOylation and protein expression in Saccharomyces cerevisiae. Utilizing a rotating wall vessel to simulate microgravity conditions, the research employed SILAC labeling and bottom-up proteomics to differentiate gravity vs SMG fo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-01-19 | PXD070877 | Pride
Rotating wall vessels Silac Simulated microgravity Proteomics Saccharomyces cerevisiae 
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