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TranscriptomicsC. elegans nasp-1 / btr-1 mutant versus wild-type N2, exposed to pathogen Bacillus thuringiensis DB27
Transcriptional profiling of C. elegans nasp-1 / btr-1 mutant worms versus wild type N2 strain, both exposed to the bacterial pathogen Bacillus thuringiensis DB27. One-condition experiment. C. elegans nasp-1 / btr-1 mutant versus N2, exposed to Bacillus thuringiensis DB27. 3 biological replicates, i...
ORGANISM(S): Caenorhabditis elegans 
2013-01-31 | E-GEOD-43905 | biostudies-arrayexpress
TranscriptomicsExpression data from a human MLL-AF6 positive AML cell line
The MLL gene on chromosome 11 fuses to the AF6 gene on chromosome 6 in a balanced chromosomal translocation that is characetristic of certain adult and pediatric human leukemias. We established a murine leukemia model of MLL-AF6 using the retroviral MLL-AF6 contruct in a bone marrow transplantation ...
ORGANISM(S): Homo sapiens 
2013-04-03 | E-GEOD-43068 | biostudies-arrayexpress
TranscriptomicsMLL-AF6 leukemia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-43069 | biostudies-arrayexpress
TranscriptomicsExpression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML
We evaluated gene expression changes in secondary recipient murine leukemia caused by retroviral overexpression of MLL-AF9. We compared wild-type (WT) leukemia cells with mutant leukemia cells after cre-mediated inactivation of a homozygous conditional allele for Ezh2, a component of the Polycomb Re...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-34961 | biostudies-arrayexpress
GenomicsEpigenetic profiling of hematopoietic stem cells and leukemia stem cells
The histone 3 lysine 79 (H3K79) methyltransferase Dot1l has been implicated in the development of leukemias bearing translocations that involve the Mixed Lineage Leukemia (MLL) gene. We identified the MLL-fusion targets in a murine MLL-AF9 leukemia model, and conducted epigenetic profiling for H3K7...
ORGANISM(S): Mus musculus 
2011-09-13 | E-GEOD-29130 | biostudies-arrayexpress
TranscriptomicsExpression profiling of primary wild type (WT), Ezh2-null and Eed-null murine MLL-AF9 AML
We evaluated gene expression changes in murine leukemia caused by retroviral overexpression of MLL-AF9. We compared wild-type (WT) leukemia cells with mutant leukemia cells after cre-mediated inactivation of homozygous conditional alleles for Ezh2 or Eed, both of which are components of the Polycomb...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-34959 | biostudies-arrayexpress
GenomicsGenome wide mapping of histone 3 lysine 79 dimethylation in MLL-AF6 murine leukemias
We report the genome wide distribution of H3K79 dimethylation in mouse MLL-AF6 positive leukemias to assess whether this epigenetic mark drives MLL-target gene expression. Examination of H3K79 dimethylation in bone marrow cells from sacrificed terminally ill MLL-AF6 positive leukemic mice. The retr...
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-43062 | biostudies-arrayexpress
TranscriptomicsExpression data from MLL-AF6 positive leukemia cells
The MLL gene on chromosome 11 fuses to the AF6 gene on chromosome 6 in a balanced chromosomal translocation that is characetristic of certain adult and pediatric human leukemias. We established a murine leukemia model of MLL-AF6 using the retroviral MLL-AF6 contruct in a bone marrow transplantation ...
ORGANISM(S): Mus musculus 
2013-04-03 | E-GEOD-43067 | biostudies-arrayexpress
TranscriptomicsExpression changes after loss of Dot1l in murine MLL-AF9 leukemia cells
MLL-fusions may induce leukemogenic gene expression programs by recruiting the histone H3K79 methyltransferase to MLL-target promoters. We evaluated gene expression changes after cre-mediated loss of Dot1l in leukemia cells obtained from mice injected with MLL-9 transformed lineage negative bone mar...
ORGANISM(S): Mus musculus 
2011-09-12 | E-GEOD-25911 | biostudies-arrayexpress
GenomicsThe Polycomb Repressive Complex 2 Is Required For MLL-AF9 Leukemia
This SuperSeries is composed of the following subset Series: GSE34959: Expression profiling of primary wild type (WT), Ezh2-null and Eed-null murine MLL-AF9 AML GSE34961: Expression profiling of secondary wild type (WT) and Ezh2-null murine MLL-AF9 AML GSE34962: Epigenetic profiling of WT and Ezh2-n...
ORGANISM(S): Mus musculus 
2012-02-22 | E-GEOD-34963 | biostudies-arrayexpress
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