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TranscriptomicsLentiviral shRNA library screen to identify growth-related genes in malignant melanoma
Little is known about genes that promote melanoma cell growth and proliferation. siRNAs may be used to address the role of individual genesin these processes. RNAi library screens were used in the past to gain a comprehensive overview of all genes involved in cell growth, proliferation, migration an...
ORGANISM(S): Homo sapiens 
2014-01-24 | E-GEOD-46675 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of siRNA transfected HEK293T cells untreated or treated with TNF-alpha to study the effect of siRNA-mediated knockdown of different genes
HEK293T cells were treated with TNF-alpha for different periods of time to study the effect of siRNA-mediated knockdown of different genes (negative control: Renilla luciferase; positive controls: TNFRSF1A, RelA; gene of interest: CASP4) on TNF-induced gene expression
ORGANISM(S): Homo sapiens 
2012-07-06 | E-MTAB-900 | biostudies-arrayexpress
TranscriptomicsThe Caenorhabditis elegans RDE-10/RDE-11 complex regulates RNAi by promoting secondary siRNA amplification
From a forward genetic screen for C. elegans genes required for RNAi, we identified rde-10 and through proteomic analysis of RDE-10-interacting proteins, we identified a protein complex containing the new RNAi factor RDE-11, the known RNAi factors RSD-2 and ERGO-1, as well as other candidate RNAi fa...
ORGANISM(S): Caenorhabditis elegans 
2012-04-07 | E-GEOD-37083 | biostudies-arrayexpress
UnknownAdenosine modification may be preferred for reducing siRNA immune stimulation.
Not available
S-EPMC4047996 | biostudies-literature
TranscriptomicsAnalysis of 22G siRNA triggered siRNA amplification and 3' 2'-O-methylated small RNAs in Caenorhabditis elegans
Small RNAs, including piRNAs, miRNAs and endogenous siRNAs, bind Argonaute proteins to form RNA-silencing complexes that target coding genes, transposons and aberrant RNAs. To assess the requirements for endogenous siRNA formation and activity in C. elegans, we developed a GFP-based sensor for the e...
ORGANISM(S): Caenorhabditis elegans 
2012-02-03 | E-GEOD-35550 | biostudies-arrayexpress
UnknownsiRNA screen identifies QPCT as a druggable target for Huntington's disease.
Not available
S-EPMC4696152 | biostudies-literature
TranscriptomicsRNA-seq analysis of vorinostat-resistant HCT116 cells following gene knockdown of GLI1 or PSMD13 with or without vorinostat treatment
Transcriptome analysis was conducted on vorinostat resistant HCT116 cells (HCT116-VR) upon knockdown of potential vorinostat resistance candidate genes in the presence and absence of vorinostat. Potential vorinostat resistance candidate genes chosen for this study were GLI1 and PSMD13, which were i...
ORGANISM(S): Homo sapiens 
2016-06-30 | E-GEOD-57871 | biostudies-arrayexpress
UnknownA multiplexed siRNA screen identifies key kinase signaling networks of brain glia.
Not available
S-EPMC9990460 | biostudies-literature
TranscriptomicsIdentification of new genes involved in human adipogenesis and fat storage
Since the worldwide increase in obesity represents a growing challenge for the health care systems, new approaches are needed to treat obesity and associated disease effectively. The food intake is primarily stored in the adipose tissue and therefore this organ is in focus to develop new anti-obesit...
ORGANISM(S): Homo sapiens 
2012-03-06 | E-GEOD-28628 | biostudies-arrayexpress
GenomicsExpression of tissue-restricted human genes following signaling or chromatin perturbations [sirna screen]
Expression of tissue-restricted human genes following signaling or chromatin perturbations [sirna screen]
PRJNA510793 | ENA
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