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TranscriptomicsTranscription profiling of human SIRS and septic shock patients reveals
Goal of the experiment: To identify correlated genes, pathways and groups of patients with systemic inflammatory response syndrome and septic shock that is indicative of biologically important processes active in these patients. Background: We measured gene expression levels and profiles of childr...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-4607 | biostudies-arrayexpress
TranscriptomicsUnique Patients from the Genomics of Pediatric SIRS and Septic Shock Investigators (GPSSSI)
This dataset is composed of the unique patients (276; at the Day 1 timepoint) that are present in the six other GEO datasets published by Hector Wong and the Genomics of Pediatric SIRS and Septic Shock Investigators. This dataset thus includes all unique patients from GSE4607, GSE8121, GSE9692, GSE1...
ORGANISM(S): Homo sapiens 
2015-05-12 | E-GEOD-66099 | biostudies-arrayexpress
GenomicsIFNg Signature in Plasma Proteome Distinguishes Pediatric Hemophagocytic Lymphohistiocytosis from Sepsis and SIRS
IFNg Signature in Plasma Proteome Distinguishes Pediatric Hemophagocytic Lymphohistiocytosis from Sepsis and SIRS
PRJNA633278 | ENA
TranscriptomicsMicroRNA profiling from pooled plasma samples of patients with sepsis and systemic inflammatory response syndrome (SIRS)
We used next-generation sequencing (NGS) to sequence and differentially quantitate miRNAs in 10 pools of plasma derived from individuals with sepsis and SIRS.Plasma pools were preferred to individual samples because they decrease the impact of individual outliers on the analysis. Total RNA was then ...
ORGANISM(S): Homo sapiens 
2016-12-01 | E-MTAB-4637 | biostudies-arrayexpress
TranscriptomicsAn integrated transcriptome and expressed variant analysis of sepsis survival and death
Background: Sepsis, a leading cause of morbidity and mortality, is not a homogeneous disease but rather a syndrome encompassing many heterogeneous pathophysiologies. Patient factors including genetics predispose to poor outcomes, though current clinical characterizations fail to identify those at gr...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-GEOD-63042 | biostudies-arrayexpress
UnknownInfluenza SIRS with Minimal Pneumonitis.
Not available
S-EPMC5005447 | biostudies-literature
TranscriptomicsIFNg Signature in Plasma Proteome Distinguishes Pediatric Hemophagocytic Lymphohistiocytosis from Sepsis and SIRS
Expression data from CD8+ T cells and CD68+ monocytes from patients with hemophagocytic lymphohistiocytosis, sepsis, and persistent systemic inflammatory response syndrome Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by pathologic immune activation in which prompt recognition...
ORGANISM(S): Homo sapiens 
2021-05-16 | GSE150707 | GEO
GenomicsA crucial role of the malate aspartate shuttle in metabolic reprogramming in TNF-induced SIRS
A crucial role of the malate aspartate shuttle in metabolic reprogramming in TNF-induced SIRS
PRJNA1334435 | ENA
TranscriptomicsTranscription profiling of brain tissue from wild type and casp1 knock-out mice treated with lipopolysaccharide or sodium chloride
The systemic inflammatory response syndrome (SIRS) is a life-threatening medical condition characterized by a severe and generalized inflammatory state that can lead to multiple organ failure and shock. The central nervous system (CNS) regulates many features of SIRS, such as fever, cardiovascular a...
ORGANISM(S): Mus musculus 
2008-03-02 | E-MEXP-1017 | biostudies-arrayexpress
TranscriptomicsA crucial role of the malate aspartate shuttle in metabolic reprogramming in TNF-induced SIRS
Tumor necrosis factor (TNF) causes a lethal systemic inflammatory response syndrome (SIRS) which is characterized by significant metabolic alterations. Based on liver RNA sequencing, we found that TNF impairs the malate-aspartate shuttle (MAS), an essential redox shuttle that transfers reducing equi...
ORGANISM(S): Mus musculus 
2025-09-30 | GSE309252 | GEO
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