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ProteomicsSit4 genetically interacts with Vps27 to regulate mitochondrial function and lifespan in Saccharomyces cerevisiae
Sit4 is a PP2A-like Ser/Thr protein phosphatase implicated in the regulation of cellular processes important for cell survival during aging. We have previously shown that SIT4 deletion promotes vacuolar acidification, mitochondrial derepression and oxidative stress resistance, increasing yeast chron...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-05-24 | PXD048450 | Pride
Sit4  vps27  vacuolar trafficking  mitochondria  iron  chronological aging 
UnknownDistinct subsets of Sit4 holophosphatases are required for inhibition of Saccharomyces cerevisiae growth by rapamycin and zymocin.
Not available
S-EPMC2772406 | biostudies-literature
UnknownActivity of the Kluyveromyces lactis Pdr5 multidrug transporter is modulated by the Sit4 protein phosphatase.
Not available
S-EPMC95276 | biostudies-literature
UnknownPP2A-Like Protein Phosphatase (Sit4) Regulatory Subunits, Sap155 and Sap190, Regulate Candida albicans' Cell Growth, Morphogenesis, and Virulence.
Not available
S-EPMC6933005 | biostudies-literature
UnknownHuman protein phosphatase PP6 regulatory subunits provide Sit4-dependent and rapamycin-sensitive sap function in Saccharomyces cerevisiae.
Not available
S-EPMC2708350 | biostudies-literature
ProteomicsThe TORC1-regulated quiescence trajectory is shaped by an Rts3-dependent feedback mechanism that limits Sit4/PP6 phosphatase activity
Four sets of MS-based proteomics experiments were performed: (1) Serine/Threonine protein phosphatases were profiled by microcystin-LR (MCLR)-based enrichment in different growth conditions; (2) TurboID-RTS3-based proximity labeling was performed to characterize the RTS3 protein neighborhood; (3) A...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-01-30 | PXD069824 | Pride
Lc-msms Yeast Saccharomyces cerevisiae Phosphatase Phosphoproteomics 
UnknownThe ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1.
Not available
S-EPMC5705342 | biostudies-literature
UnknownTORC1 regulates the transcriptional response to glucose and developmental cycle via the Tap42-Sit4-Rrd1/2 pathway in Saccharomyces cerevisiae.
Not available
S-EPMC8103650 | biostudies-literature
UnknownMds3 regulates morphogenesis in Candida albicans through the TOR pathway.
Not available
S-EPMC2897559 | biostudies-literature
UnknownTor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae.
Not available
S-EPMC2276367 | biostudies-literature
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