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ProteomicsSite-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling
HOIP, the catalytic component of the Linear Ubiquitin chain Assembly Complex (LUBAC), is a critical regulator of inflammation. However, how HOIP itself is regulated to control inflammatory responses is unclear. Here, we discover that site-specific ubiquitination of K784 within HOIP promotes Tumour N...
ORGANISM(S): Homo sapiens (Human) 
2020-08-31 | PXD021217 | Pride
Site-specific ubiquitination of the e3 ligase hoip regulates apoptosis and immune signaling 
GenomicsPromoters Active in Interphase are Bookmarked during Mitosis by Ubiquitination
We analyzed genome-wide modification of chromatin by ubiquitination in human cells and whether this mark changes through the cell cycle using modified ChIP-seq technique (ChAP-seq). Chromatin affinity purification was based on a standard ChIP method with modification of a two-step affinity purificat...
ORGANISM(S): Homo sapiens 
2013-04-04 | E-GEOD-45771 | biostudies-arrayexpress
GenomicsThe Mediator complex subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination
The Mediator complex orchestrates multiple transcription factors with the Pol II apparatus for precise transcriptional control. However, its interplay with the surrounding chromatin remains poorly understood. Here, we analyze differential histone modifications between WT and MED23-/- (KO) cells and ...
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-59518 | biostudies-arrayexpress
ProteomicsIdentification of ubiquitination sites on protein CSDE1 in SHSY5Y cells.
This bottom-up proteomics dataset provides a global map of post-translational modifications (PTMs) on the RNA-binding protein CSDE1 in human neuroblastoma SHSY5Y cells. The data was acquired to survey the modification landscape of CSDE1, with a particular observation that lysine (K) residues display...
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD073844 | Pride
Mkrn2 Csde1 Ubiquitination site 
ProteomicsSite-Specific Ubiquitination of Pathogenic Huntingtin Attenuates its Deleterious Effects
Huntington’s disease (HD) is a progressive incurable neurodegenerative disorder characterized by motor and neuropsychiatric symptoms. It is caused by expansion of a CAG triplet in the N-terminal domain of exon 1 in the huntingtin (HTT) gene that codes for an expanded polyglutamine (polyQ) stretch in...
ORGANISM(S): Rattus rattus (Black rat) 
2020-06-30 | PXD019553 | Pride
Huntingtin ubiquitination 
ProteomicsQuantitative proteomics reveals extensive lysine ubiquitination in Arabidopsis thaliana
In this study, we describe an antibody-based approach to enrich ubiquitinated peptides from vegetative tissues for detection via peptide mass spectrometry. This enrichment method can be coupled with isobaric labeling to enable quantification from up to 18-multiplexed samples. This approach identifie...
ORGANISM(S): Arabidopsis Thaliana (ncbitaxon:3702) 
2024-07-31 | MSV000095496 | MassIVE
ProteomicsSite-Specific Ubiquitination of Pathogenic Huntingtin Attenuates its Deleterious Effects- PART2
Huntington’s disease (HD) is a progressive incurable neurodegenerative disorder characterized by motor and neuropsychiatric symptoms. It is caused by expansion of a CAG triplet in the N-terminal domain of exon 1 in the huntingtin (HTT) gene that codes for an expanded polyglutamine (polyQ) stretch in...
ORGANISM(S): Homo sapiens (Human) 
2020-06-30 | PXD019552 | Pride
Ubiquitination huntingtin 
ProteomicsQuantitative proteomic atlas of phosphorylation and ubiquitination reveals Epn2-mediated endocytosis dysfunction in α-synuclein transgenic mice
Progression through neuronal loss of substantia nigra pars compacta with Parkinson’s disease depends on various protein post-translational modifications mainly comprising phosphorylation, ubiquitination, acetylation, and methylation. Phosphorylation and ubiquitination regulate major physiological ch...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-28 | PXD013965 | Pride
Phosphorylation Ubiquitination Parkinson’s disease Quantitative proteomics Endocytosis 
UnknownAllosteric mechanism for site-specific ubiquitination of FANCD2.
Not available
S-EPMC7035956 | biostudies-literature
UnknownSite-specific ubiquitination affects protein energetics and proteasomal degradation.
Not available
S-EPMC8513624 | biostudies-literature
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